 |
 |
|
Home |
Current Issue |
Past Issues |
Audio/Video |
CME |
Collections |
In the Clinic |
Mobile |
Subscribe |
Tools |
Help |
ACP Online
|
|
Articles 
Ramachandran S. Vasan, Lisa M. Sullivan, Peter W.F. Wilson, Christopher T. Sempos, Johan Sundström, William B. Kannel, Daniel Levy, and Ralph B. D'Agostino These researchers estimated the 10-year coronary heart disease event rate for each person in a nationally representative sample by using the individual's risk factors and the Framingham Study risk equation. The findings suggest that in the United States, borderline levels of risk factors account for a small proportion of coronary heart disease events.
Guenther Boden, Karin Sargrad, Carol Homko, Maria Mozzoli, and T. Peter Stein In a small group of obese, diabetic patients, 2 weeks of a low-carbohydrate diet led to spontaneous reduction in energy intake because, despite the carbohydrate restriction, the participants did not increase their fat and protein intake. Twenty-four-hour blood glucose profiles, insulin sensitivity, and hemoglobin A1c values all improved.
Héctor F. Escobar-Morreale, José I. Botella-Carretero, Manuel Gómez-Bueno, José M. Galán, Vivencio Barrios, and José Sancho The authors gave women with overt primary hypothyroidism combinations of L-thyroxine (synthetic T4) plus liothyronine (synthetic T3) in doses that mimic the normal secretion of the thyroid gland. Even though combination therapy did not offer any objective advantage over L-thyroxine alone, the patients preferred it.
Shumin M. Zhang, Julie E. Buring, I-Min Lee, Nancy R. Cook, and Paul M. Ridker Contrary to a recent large study, elevated plasma C-reactive protein levels were not associated with an increased risk for developing colorectal cancer in apparently healthy women. The results suggest that low-grade inflammation does not play an important role in increasing the risk for colorectal cancer.
Updates
Donald G. Vidt This year's Update in Nephrology and Hypertension incorporates articles on clinical hypertension; proteinuria, lipids, and renal disease; blood pressure, angiotensin II antagonists, and renal disease; smoking and renal disease; hypertension and coronary artery disease; and chronic kidney disease detection.
Reviews
Karl E. Anderson, Joseph R. Bloomer, Herbert L. Bonkovsky, James P. Kushner, Claus A. Pierach, Neville R. Pimstone, and Robert J. Desnick The authors review the clinical manifestations, pathophysiology, and genetics of the acute porphyrias and provide advice about diagnosis and treatment based on the clinical literature and their experience.
Nasia Safdar, Jason P. Fine, and Dennis G. Maki Paired quantitative blood culture is the most accurate test for diagnosis of intravascular device–related bloodstream infection. However, most other methods studied showed acceptable sensitivity and specificity (both > 0.75). Physicians should culture catheters only if they suspect intravascular device–related bloodstream infection.
Editorials
Cynthia Mulrow and William Kussmaul Researchers have proposed that physicians should advise all of their patients over age 55 to take a polypill containing treatments for many cardiovascular risk factors rather than testing them for risk factors and treating selectively. In this issue, Vasan and colleagues describe the prevalence of risk factors for cardiovascular disease in the United States. This evidence, along with other data, suggests that a preventive polypill is the wrong approach for this population.
George A. Bray In this issue, Boden and colleagues show that the reduction in energy intake during very-low-carbohydrate diets accounts for the observed weight loss. The explanation for weight loss after restricting carbohydrate applies to many different diets. Because weight loss during a diet usually plateaus after a while, patients may benefit from switching between diets with different approaches to food restriction.
Letters When Most Doctors Are Women
Breast Cancer after Childhood Cancer
Evidence for Expanding Physician Supply
Drug-Induced Thrombocytopenia: An Updated Systematic Review
Sarcoidosis Presenting with Massive Involvement of the Nervous System
Salvatore Sollima, Francesco Croce, Chiara Scalamogna, Ilaria Caramma, and Spinello Antinori Rapid Diagnostic Test for Plasmodium falciparum in 32 Marines Medically Evacuated from Liberia with a Febrile Illness
Brian Susi, Tim Whitman, David L. Blazes, Timothy H. Burgess, Gregory J. Martin, and Daniel Freilich Two Patients with Acute Liver Injury Associated with Use of the Herbal Weight-Loss Supplement Hydroxycut
Choreoathetosis with Dopamine
Correction: Office-Based Testing for Fecal Occult Blood
Correction: Prolonged Coagulopathy Related to Superwarfarin Overdose
Judith Overmier
Thomas F. Mulrooney
| ||||||||||||||||||||||||||||||||||||||||||
In this Issue
Articles
Previous Issue