 |
 |
|
Home |
Current Issue |
Past Issues |
In the Clinic |
ACP Journal Club |
CME |
Collections |
Audio/Video |
Mobile |
Subscribe |
Tools |
Help |
ACP Online
|
|
Articles 
Seamus P. Whelton, Ashley Chin, Xue Xin, and Jiang He Exercise reduces blood pressure in both hypertensive and normotensive persons. An increase in aerobic physical activity should be considered an important component of lifestyle modification for prevention and treatment of high blood pressure.
Carmine G. Fanelli, Simone Pampanelli, Francesca Porcellati, Paolo Rossetti, Paolo Brunetti, and Geremia B. Bolli When the goal of insulin therapy in type 1 diabetes mellitus is near-normoglycemia, splitting the evening insulin treatment regimen into short-acting insulin at dinner and neutral protamine Hagedorn (NPH) insulin at bedtime reduces the risks for nocturnal hypoglycemia and hypoglycemia unawareness and decreases the hemoglobin A1c value compared with mixing short-acting insulin and NPH insulin at dinner.
Hossein Ardeschir Ghofrani, Ralph Wiedemann, Frank Rose, Horst Olschewski, Ralph Theo Schermuly, Norbert Weissmann, Werner Seeger, and Friedrich Grimminger Although limited by the small sample and lack of long-term observations, this study shows that oral sildenafil is a potent pulmonary vasodilator that acts synergistically with inhaled iloprost to cause pulmonary vasodilatation in both severe pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension.
Brief Communications
Takeshi Hozumi, Marc Eisenberg, Kenichi Sugioka, Aravind R. Kokkirala, Hiroyuki Watanabe, Masakazu Teragaki, Junichi Yoshikawa, and Shunichi Homma In this study, coronary flow reserve decreased after a single high-fat meal in young healthy men. High-fat meals may be detrimental to coronary microcirculation.
Nader Rifai, Julie E. Buring, I-Min Lee, JoAnn E. Manson, and Paul M Ridker C-reactive protein (CRP) predicts risk for future cardiovascular events in asymptomatic persons. However, because CRP also predicts total mortality, its specificity for vascular disease is uncertain. This study found that CRP level appears to independently predict cardiovascular events but not cancer.
Updates
Neal S. Young This Update discusses many aspects of aplastic anemia, including its immune pathophysiology, its place as a hematologic disease and as an immune-mediated syndrome, the differential diagnosis of bone marrow failure, the possibility of an infectious cause, available treatments, and evolution to other hematologic diseases and late clonal events.
Editorials
Andrew W. Norris and Lori M.B. Laffel In this issue, Fanelli and colleagues compared split-dose and mixed-dose insulin regimens in patients with type 1 diabetes mellitus. Evidence now suggests that for a selected group of persons with type 1 diabetes mellitus, an extra shot at bedtime should be considered, although newer insulin analogues may yield additional approaches and benefits in the near future.
Wolfgang Koenig and Mark B. Pepys Consistent results from more than 15 well-conducted prospective studies in initially healthy persons have shown a strong and independent association between the circulating C-reactive protein level and cardiovascular end points. As Rifai and colleagues show in this issue, the empirical measurement of C-reactive protein is a powerful predictor of cardiovascular risk regardless of the underlying mechanisms.
Robert G. Badgett and Cynthia D. Mulrow PIER (Physicians' Information and Education Resource), a new information product for the clinician, will be available beginning April 11 to American College of Physicians–American Society of Internal Medicine members (http://
Letters Helicobacter pylori Eradication Therapy for Nonulcer Dyspepsia
Acute Exacerbations of Chronic Obstructive Pulmonary Disease
Laser Removal of Radiation Tattoos
Alfred I. Tauber Consider an addition to the medical record—one that heretofore was implicitly present but now must be made explicit: Insert a section called Ethical Concerns.
Jack Coulehan
John F. Whitney and Gary H. Lyman
J. Michael Kilby
Nancy Fitz-Hugh Meneely
| |||||||||||||||||||||||||||||||||||||||||||||||
In this Issue
Articles
Previous Issue
er.acponline.org/