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Articles 
Kathleen M. McTigue, Joanne M. Garrett, and Barry M. Popkin Marked ethnic-based differences were found in rates of weight gain in young U.S. adults, with later birth cohorts experiencing earlier onset of obesity. To alter the course of obesity in the United States, interventions should target young adults, especially those of minority ethnic groups.
Henk-Jan Baarslag, Edwin J.R. van Beek, Maria M.W. Koopman, and Jim A. Reekers Duplex ultrasonography may be the method of choice for initial diagnosis of patients with suspected thrombosis of the upper extremities. However, in patients with isolated flow abnormalities, contrast venography should be performed.
Mary McGrae McDermott, Philip Greenland, Kiang Liu, Jack M. Guralnik, Lillian Celic, Michael H. Criqui, Cheeling Chan, Gary J. Martin, Joseph Schneider, William H. Pearce, Lloyd M. Taylor, and Elizabeth Clark The ankle brachial index is more closely associated with leg function in persons with peripheral arterial disease than is intermittent claudication or other leg symptoms. These data support the use of the ankle brachial index to identify abnormal lower-extremity function.
Brief Communications
Javier A. Adachi, John J. Mathewson, Zhi-Dong Jiang, Charles D. Ericsson, and Herbert L. DuPont Contamination with enteropathogenic Escherichia coli was common in samples of Mexican tabletop sauces from Guadalajara restaurants.
Academia and Clinic
Thierry Poynard, Mona Munteanu, Vlad Ratziu, Yves Benhamou, Vincent Di Martino, Julien Taieb, and Pierre Opolon This study found that conclusions based on recognized, good methodology had no clear survival advantage. To better convince clinicians of the long-term utility of evidence-based medicine, better prognostic factors should be developed.
Updates
Muhammad Asim Khan Types of spondyloarthropathies (ankylosing spondylitis, reactive arthritis, psoriatic arthritis, and enteropathic arthritis) are discussed, along with pathogenesis, genetic aspects, management, and new therapies.
Reviews
J. Bruce Smith and Mark K. Haynes This review explores some of the answers that new molecular techniques have provided to a series of clinical questions: 1) Who gets rheumatoid arthritis, and what determines its severity? 2) How do inflammatory cells accumulate in affected tissues? 3) What do T cells do in the synovium? 4) How do the cells in the synovium effect tissue destruction?
Editorials
Robert C. Whitaker In this issue, McTigue and colleagues describe the natural history of obesity in young adults and have verified what can be strongly inferred from previous research—that a greater proportion of U.S. adults become obese each year.
Letters The CONSORT Statement: Explanation and Elaboration
Stanley P. Ballou
Stuart Oserman
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