 |
 |
|
Home |
Current Issue |
Past Issues |
In the Clinic |
ACP Journal Club |
CME |
Collections |
Audio/Video |
Mobile |
Subscribe |
Tools |
Help |
ACP Online
|
|
Articles 
Elaine M. Hylek, Susan Regan, Alan S. Go, Robert A. Hughes, Daniel E. Singer, and Steven J. Skates Steady-state warfarin dose, advanced age, and extreme elevation in international normalized ratio (INR) are risk factors for prolonged delay in return of the INR to within the therapeutic range. Decompensated congestive heart failure and active cancer greatly increase this risk.
G. Boudewijn C. Vasbinder, Patricia J. Nelemans, Alfons G.H. Kessels, Abraham A. Kroon, Peter W. de Leeuw, and Jos M.A. van Engelshoven Computed tomography angiography and gadolinium-enhanced three-dimensional magnetic resonance angiography seem to be preferred in patients referred for evaluation of renovascular hypertension. However, because few studies of these tests have been published, further research is recommended.
Marc Boogaerts, Drew J. Winston, Eric J. Bow, Gary Garber, Annette C. Reboli, Anthony P. Schwarer, Nicolas Novitzky, Angelika Boehme, Elisabeth Chwetzoff, Karel De Beule the Itraconazole Neutropenia Study Group* Itraconazole and amphotericin B have at least equivalent efficacy when used as empirical antifungal therapy in neutropenic patients with cancer. However, itraconazole is associated with significantly less toxicity.
J. Taylor Hays, Richard D. Hurt, Nancy A. Rigotti, Raymond Niaura, David Gonzales, Michael J. Durcan, David P.L. Sachs, Troy D. Wolter, A. Sonia Buist, J. Andrew Johnston, and Jonathan D. White In persons who had stopped smoking during 7 weeks of bupropion treatment, sustained-release bupropion for 12 months delayed smoking relapse and resulted in less weight gain compared with patients who received placebo.
Brief Communications
Stuart Johnson, Sara A. Kent, Kevin J. O'Leary, Michelle M. Merrigan, Susan P. Sambol, Lance R. Peterson, and Dale N. Gerding Toxin A variant strains of Clostridium difficile cause serious disease and are undetectable in clinical laboratories that use only toxin A immunoassays for C. difficile testing.
Updates
Allan D. Sniderman, Thea Scantlebury, and Katherine Cianflone The authors review the pathophysiology of hypertriglyceridemic hyperapoB, focusing on the changes in lipoprotein particle number and composition rather than lipoprotein lipid levels; summarize the in vitro and in vivo evidence that small, dense low-density lipoprotein (LDL) are more atherogenic than normal larger, buoyant LDL; and delineate the particularly high-risk state conferred by increased numbers of small, dense LDL.
Editorials
Henry I. Bussey In this issue, Hylek and colleagues provide valuable new information that should improve the ability to manage excessive warfarin anticoagulation and reduce risk for bleeding. In the absence of more definitive data from prospective studies, this study may help physicians decide who should receive vitamin K, how much vitamin K is required, and how soon a follow-up international normalized ratio is indicated.
Frank Davidoff, Catherine D. DeAngelis, Jeffrey M. Drazen, The Editors, John Hoey, Liselotte Højgaard, Richard Horton, Sheldon Kotzin, Magne Nylenna, A. John P.M. Overbeke, Harold C. Sox, Martin B. Van Der Weyden, and Michael S. Wilkes The authors of this editorial belong to the International Committee of Medical Journal Editors (ICMJE). They ask investigators to use the revised ICMJE requirements on publication ethics to guide the negotiation of contracts with corporate sponsors of research. Those contracts should give the researchers a substantial say in trial design, access to the raw data, responsibility for data analysis and interpretation, and the right to publish. The co-signers of this editorial are unlikely to publish articles when the authors did not enjoy these basic rights.
On Being a Doctor
Brendan M. Reilly Looking back now, knowing what I know today about this place, it is easy to feel naive or stupid about what happened that night at Charlie's house. But this was 25 years ago, so I will tell you what I saw that night and how it strikes me now. But I may never know what really happened.
Letters Erythropoietin for Total Hip Joint Arthroplasty
Judith A. O'Donnell
Kenneth B. Desser
Tom Reynolds
Rae Varcoe
William H. Frishman This year's Update in Cardiology features key reports in major areas of cardiovascular medicine: prevention, unstable coronary syndromes, chronic cardiovascular disease, arrhythmias, and peripheral vascular disease. | |||||||||||||||||||||||||||||||||||||||||||||||||
In this Issue
Articles
Previous Issue