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Articles 
Howard N. Hodis, Wendy J. Mack, Roger A. Lobo, Donna Shoupe, Alex Sevanian, Peter R. Mahrer, Robert H. Selzer, Chao-ran Liu, Ci-hua Liu, Stanley P. Azen for the Estrogen in the Prevention of Atherosclerosis Trial Research Group* Overall, the average rate of progression of subclinical atherosclerosis was slower in healthy postmenopausal women taking unopposed estrogen replacement therapy with 17ß-estradiol than in women taking placebo. Progression of subclinical atherosclerosis decreased in women who did not take lipid-lowering medication but not in those who took these medications.
Lisa M. Demeter, Michael D. Hughes, Robert W. Coombs, J. Brooks Jackson, Janet M. Grimes, Ronald J. Bosch, Susan A. Fiscus, Stephen A. Spector, Kathleen E. Squires, Margaret A. Fischl, and Scott M. Hammer The HIV-1 RNA level and CD4 cell count achieved at 8 weeks of indinavir, zidovudine, and lamivudine therapy are important predictors of subsequent virologic and clinical outcomes.
Carmen Castaneda, Patricia L. Gordon, Katherine Leigh Uhlin, Andrew S. Levey, Joseph J. Kehayias, Johanna T. Dwyer, Roger A. Fielding, Ronenn Roubenoff, and Maria Fiatarone Singh By improving muscle mass, nutritional status, and function, resistance training seems to be effective against the catabolism of a low-protein diet and uremia in patients with renal failure.
Brief Communications
Hiroaki Kawano, Takeshi Motoyama, Masamichi Ohgushi, Kiyotaka Kugiyama, Hisao Ogawa, and Hirofumi Yasue In premenopausal women with variant angina, the authors documented a cyclic variation in endothelial function and the frequency of myocardial ischemia that was associated with the variation in estrogen levels.
Academia and Clinic
Lise L. Kjaergard, John Villumsen, and Christian Gluud Inadequate generation of the allocation sequence, allocation concealment, and double blinding lead to exaggerated estimates of intervention benefit and may contribute to discrepancies between the results of large randomized trials and small randomized trials in meta-analyses.
Reviews
Theodore S. Takata, Richard L. Page, and Jose A. Joglar The authors provide general information on the technology and operation of automated external defibrillators, summarize the experience of trials of these devices (in emergency medical systems and in special environments), and discuss legislative and legal concerns.
Editorials
John B. Copley Castaneda and colleagues' results, reported in this issue, suggest that resistance training is a safe and effective countermeasure to the negative effects of protein restriction on muscle mass accretion, protein utilization, nutritional status, and muscle function in patients with chronic kidney disease. Their study provides a method for improving safety when protein-restricted diets are used, as well as a means for enhancing the overall health of patients with chronic kidney disease.
Pamela Charney In this issue, Kawano and colleagues elegantly explore the relationship of endogenous hormone levels to arterial function and coronary ischemic symptoms. Consideration of the interaction of the menstrual cycle and coronary artery disease may affect clinical practice in the not-distant future.
Letters Clinical Trial Acronyms
Methotrexate in Giant-Cell Arteritis
Nonhypoglycemic Effects of Thiazolidinediones
New Psychopharmacologic Treatment Strategies
Albumin Meta-Analysis
Clinical Librarianship
Sympathetic Neurocirculatory Failure in Parkinson Disease: Evidence for an Etiologic Role of Severe Neurotoxicity of Cefepime in Uremic Patients
Abraham Verghese By being attuned to character, not just through appearance but particularly through dialogue, we will remember the voice of the patient, even though it is the voice of medicine that we record in the chart. To hear the voice of the patient preserves our capacity to imagine the suffering of the patient.
Roger Luckmann
Kim A. Carmichael
Rae Varcoe
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