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Articles 
Pierre-Jean Guillausseau, Pascale Massin, Danièle Dubois-LaForgue, José Timsit, Marie Virally, Henri Gin, Eric Bertin, Jean-Frédéric Blickle, Béatrice Bouhanick, Juliette Cahen, Sophie Caillat-Zucman, Guillaume Charpentier, Pierre Chedin, Christèle Derrien, Pierre-Henri Ducluzeau, André Grimaldi, Bruno Guerci, Edgar Kaloustian, Arnaud Murat, Frédérique Olivier, Michel Paques, Véronique Paquis-Flucklinger, Béatrice Porokhov, Julien Samuel-Lajeunesse, and Bernard Vialettes Maternally inherited diabetes and deafness (MIDD) is related to a point mutation of mitochondrial DNA. This study suggests that MIDD has a specific clinical profile that may help identify diabetic patients for mitochondrial DNA testing.
Andreas Fritsche, Norbert Stefan, Hans Häring, John Gerich, and Michael Stumvoll Avoidance of hypoglycemia in patients with type 1 diabetes who have hypoglycemia unawareness seems to restore hypoglycemia awareness, primarily by increasing ß-adrenergic sensitivity.
Jean-François Yale, Thomas R. Valiquett, Mahmoud N. Ghazzi, Janet K. Owens-Grillo, Randall W. Whitcomb, Howard L. Foyt for the Troglitazone Triple-Therapy Study Group* Troglitazone at a dosage of 400 mg/d decreased hemoglobin A1clevels when used in combination with sulfonylurea and metformin. Other drugs in the thiazolidinedione class may therefore offer an effective alternative to insulin for patients treated with sulfonylurea and metformin who do not achieve adequate glycemic control.
Laura M. Dember, Vaishali Sanchorawala, David C. Seldin, Daniel G. Wright, Michael LaValley, John L. Berk, Rodney H. Falk, and Martha Skinner Dose-intensive intravenous melphalan with autologous blood stem-cell transplantation improves the nephrotic syndrome in patients with AL amyloidosis–associated renal disease. The benefit is largely limited to patients achieving eradication of the underlying plasma cell dyscrasia.
Brief Communications
Ellen F. Binder, Daniel B. Williams, Kenneth B. Schechtman, Donna B. Jeffe, and Wendy M. Kohrt In women 75 years of age or older, hormone replacement therapy improved the lipoprotein profile to the extent observed previously in younger postmenopausal women. Further studies are needed to evaluate whether these effects protect against coronary heart disease in this population.
Reviews
Christine M. Hogan and Scott M. Hammer This review, the first of two parts, describes current information about host factors in HIV acquisition and progression and discusses how this knowledge can be used to prevent and treat HIV infection.
Position Papers
American College of Physicians–American Society of Internal Medicine* This position paper addresses physicians' joining to negotiate patient care and the working environment in which patient services are provided. Physicians in nonintegrated private practices should be able to meet and communicate among themselves to negotiate primarily with health care plans about issues that affect quality and access. However, the College opposes strikes or any joint action by physicians that would deny or limit services to patients or result in price-fixing or other anticompetitive behavior.
Editorials
Nathan Fischel-Ghodsian The article by Guillausseau and colleagues in this issue confirms that the diabetes phenotype in maternally inherited diabetes and deafness is quite different from that in other known forms of diabetes. This has clinical implications that make it imperative for the internist to be aware of the syndrome.
David C. Hsia The position paper by the American College of Physicians–American Society of Internal Medicine in this issue deserves the utmost commendation for raising one of medicine's most important current issues: Are physicians independent professionals, or agents for plans?
Anthony L. Komaroff The supplement accompanying this issue addresses the study of symptoms. Symptom research is a long-neglected field, one that may now be poised to produce important new insights that will improve the functional status of people everywhere and make the physician's job more gratifying.
On Being a Doctor
Daniel R. Feikin The world she inhabited was fleeting, stitched together extemporaneously from some retained repository of information. Yet, something essentially human had been preserved.
Letters Inhaled Insulin: A Proof-of-Concept Study
Body Size and Vertebral Fractures
Airway Adrenaline in Patients with Severe Cardiac Disease
Salary Equity among Male and Female Internists
Isoniazid-Induced ß-Hydroxybutyric Acidosis
Correction: Antiretroviral Therapy and HIV Shedding
Rocco Vivenzio
Gary H. Lyman
Paula Tatarunis
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