TABLE OF CONTENTS 17 October 2000 Volume 133 Issue 8	Previous Issue  |  Next Issue

Cost-Effectiveness of Colonoscopy in Screening for Colorectal Cancer

Amnon Sonnenberg, Fabiola Delcò, and John M. Inadomi

Colonoscopy is a cost-effective means of screening for colorectal cancer because it reduces mortality at relatively low incremental costs. Low compliance rates render colonoscopy every 10 years the most cost-effective primary screening strategy for colorectal cancer.

Smoking Is Related to Albuminuria and Abnormal Renal Function in Nondiabetic Persons

Sara-Joan Pinto-Sietsma, Jaap Mulder, Wilbert M.T. Janssen, Hans L. Hillege, Dick de Zeeuw, and Paul E. de Jong

Smoking was found to be associated with albuminuria and abnormal renal function. However, these associations are less pronounced or absent in former smokers.

Prevalence of Type 2 Diabetes Mellitus among Persons with Hepatitis C Virus Infection in the United States

Shruti H. Mehta, Frederick L. Brancati, Mark S. Sulkowski, Steffanie A. Strathdee, Moyses Szklo, and David L. Thomas

According to this national survey, type 2 diabetes occurs more often in persons with hepatitis C virus infection who are older than 40 years of age.

Long-Term Outcomes of Scleroderma Renal Crisis

Virginia D. Steen and Thomas A. Medsger, Jr.

Renal crisis in patients with scleroderma can be effectively managed when hypertension is aggressively controlled with angiotensin-converting enzyme inhibitors. Patients should continue taking these drugs after beginning dialysis.

Diagnosis and Management of Infections Involving Implantable Electrophysiologic Cardiac Devices

Jimmy Dy Chua, Bruce L. Wilkoff, Irene Lee, Nour Juratli, David L. Longworth, and Steven M. Gordon

For infections related to implantable electrophysiologic devices, complete device removal and antimicrobial therapy allow timely, successful reimplantation at a remote anatomic site without substantial risk for surgical mortality or recurrent infection.

Better Access to Information about Clinical Trials

Alexa T. McCray

This paper briefly reviews existing clinical trials registries, discusses challenges in building registries, and reviews some of the benefits of registries.

Cachexia

Donald P. Kotler

Recent advances in the understanding of selected aspects of cachexia are discussed. Among these are changes in body composition, food intake, intermediary metabolism, energy balance, cytokine regulation, and recent therapeutic initiatives.

Osteoarthritis: New Insights. Part 1: The Disease and Its Risk Factors

David T. Felson, Reva C. Lawrence, Paul A. Dieppe, Rosemarie Hirsch, Charles G. Helmick, Joanne M. Jordan, Raynard S. Kington, Nancy E. Lane, Michael C. Nevitt, Yuqing Zhang, MaryFran Sowers, Timothy McAlindon, Tim D. Spector, A. Robin Poole, Susan Z. Yanovski, Gerard Ateshian, Leena Sharma, Joseph A. Buckwalter, Kenneth D. Brandt, and James F. Fries

Part 1 of this two-part conference addresses a new understanding of what osteoarthritis is and the risk factors that predispose to disease occurrence.

Prevention and Treatment of Colorectal Cancer: Pay Now or Pay Later

James D. Lewis

It now appears almost certain that screening colonoscopy can effectively reduce colorectal cancer–related mortality and is probably more effective than fecal occult blood testing, flexible sigmoidoscopy, or both. An important remaining question is how much this strategy will cost. In this issue, Sonnenberg and colleagues attempt to answer that question.

An Association between Hepatitis C Virus Infection and Type 2 Diabetes Mellitus: What Is the Connection?

Graeme J.M. Alexander

The association between chronic hepatitis C virus infection and type 2 diabetes mellitus, reported by Mehta and colleagues in this issue, seems genuine. However, numerous questions must still be addressed, most notably those regarding the nature of the link between the disorders.

Magic in the Web of It

Lori A. Borella

During a rural medicine clerkship, a medical student encounters a surprising link to her past.

Drug Effects on Driving Performance

Dick de Waard and Karel A. Brookhuis

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Thomas H. Lee, Jessica Dudley, and Harold J. Demonaco

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James T. Angello and Howard M. Druce

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John M. Weiler, George Woodworth, and Ginger Watson—RESPONSE

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Rosiglitazone Toxicity

Ravi Sudhir Ravinuthala and Uday Nori

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Over-the-Counter Availability of H₂-Receptor Antagonists and Gastric Cancer

Ichiro Yoshikawa, Ikuo Murata, and Makoto Otsuki

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Correction: Walnuts and Serum Lipid Profile

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Correction: Calcific Constrictive Pericarditis

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Medical Writings: Book Notes 

Hormone Therapy and the Brain: A Clinical Perspective on the Role of Estrogen

Murray Grossman

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Therapy of Digestive Disorders: A Companion to Sleisenger and Fortran's Gastroenterological and Liver Disease

Michael S. Shapiro

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Current Clinical Issues  

Vaccines Today

Aaron Levin

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Ad Libitum 

Making the Rounds

George Young

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To Nowhere

Zijad Durakovic

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Winter Desire

Zijad Durakovic

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Ancillary Content 

Book Listings

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Medical Notices

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Summaries for Patients 

Screening Strategies for Colorectal Cancer

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Smoking and Kidney Function in Persons without Diabetes

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The Association between Infection with Hepatitis C Virus and Diabetes

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Long-Term Outcomes of Scleroderma Renal Crisis

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Infections Involving Implantable Cardiac Devices

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UPDATES FROM THE ANNUAL SESSION 

Update in Oncology

Lynn M. Schuchter and Daniel G. Haller

Among the many important papers in the field of oncology published in 1999, this Update focuses on studies of breast cancer, cervical cancer, multiple myeloma, colorectal cancer, and prostate cancer.

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