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Articles 
Judith S. Currier, Paige L. Williams, Susan L. Koletar, Susan E. Cohn, Robert L. Murphy, Alison E. Heald, Richard Hafner, Ehab L. Bassily, Howard M. Lederman, Charles Knirsch, Constance A. Benson, Hernan Valdez, Judith A. Aberg, and J. Allen McCutchan Prophylaxis against Mycobacterium avium complex infection can safely be withdrawn or withheld in adults with HIV infection whose CD4+ cell count increases during antiretroviral therapy.
Patrick J. Stiff, Judith Veum-Stone, Hillard M. Lazarus, Lois Ayash, John R. Edwards, Armand Keating, John P. Klein, David J. Oblon, Thomas C. Shea, Stephan Thomé, and Mary M. Horowitz Some patients with ovarian cancer seem to have good outcomes after autotransplantation, although several biases may have affected these observations. Phase III trials are needed to compare outcomes after autotransplantation with outcomes after conventional chemotherapy.
Andrea Z. LaCroix, Susan M. Ott, Laura Ichikawa, Delia Scholes, and William E. Barlow In healthy older adults, low-dose hydrochlorothiazide preserves bone mineral density at the hip and spine. If the modest effects observed over 3 years are accumulated over 10 to 20 years, they may explain the one-third reduction in risk for hip fracture associated with thiazide in many epidemiologic studies.
Ezekiel J. Emanuel, Diane Fairclough, Brian C. Clarridge, Diane Blum, Eduardo Bruera, W. Charles Penley, Lowell E. Schnipper, and Robert J. Mayer Requests for euthanasia and physician-assisted suicide are likely to decrease as training in end-of-life care improves and the ability of physicians to provide this care to their patients is enhanced.
Brief Communications
Mathew S. Maurer, Wahida Karmally, Harold Rivadeneira, Michael K. Parides, and Daniel M. Bloomfield Meal ingestion and head-up tilt-table testing are associated with increasing occurrences of symptomatic hypotension; 22% of functionally independent elderly persons in this study had symptomatic hypotension after eating a meal and undergoing tilt-table testing.
Toru Suzuki, Hirohisa Katoh, Yasuhiro Tsuchio, Akira Hasegawa, Masahiko Kurabayashi, Atsushi Ohira, Katsuhiko Hiramori, Yasunari Sakomura, Hiroshi Kasanuki, Shingo Hori, Naoki Aikawa, Satoshi Abe, Chuwa Tei, Yoshihisa Nakagawa, Masakiyo Nobuyoshi, Kazuhiko Misu, Tetsuya Sumiyoshi, and Ryozo Nagai Levels of smooth-muscle myosin heavy-chain protein can be used to diagnose aortic dissection soon after symptom onset. This assay had the greatest diagnostic value in patients with proximal lesions.
Perspectives
Terry A. Jacobson The robust findings of trials examining lipid-lowering drug therapy do not necessarily justify targeting low-density lipoprotein cholesterol to its lowest possible level, and the argument expressed by the phrase "the lower the better" is clearly not evidence based.
Editorials
Gisele A. Sarosy and Eddie Reed In this issue, Stiff and colleagues report on the use of autologous stem-cell transplantation in patients with ovarian cancer. To determine the role of this therapy, the available data must be compared with data from other treatment strategies in similar patients. This editorial compares "best-case scenario" data on several approaches.
On Being a Doctor
Dean Gianakos The sign on the front door reads: Practitioner of the Alternative, Healing Arts. Rugs, curtains, and a fireplace in the corner warmed me. A friendly nurse escorted me to an examination room.
Letters Responding to Intractable Terminal Suffering
Daniel P. Sulmasy, Wayne A. Ury, Judith C. Ahronheim, Mark Siegler, Leon Kass, John Lantos, Robert A. Burt, Kathleen Foley, Richard Payne, Carlos Gomez, Thomas J. Krizek, Edmund D. Pellegrino, and Russell K. Portenoy Palliative Treatment of Last Resort and Assisted Suicide
Daniel P. Sulmasy, Wayne A. Ury, Judith C. Ahronheim, Mark Siegler, Leon Kass, John Lantos, Robert A. Burt, Kathleen Foley, Richard Payne, Carlos Gomez, Thomas J. Krizek, Edmund D. Pellegrino, and Russell K. Portenoy Publication of Papers on Assisted Suicide and Terminal Sedation
Daniel P. Sulmasy, Wayne A. Ury, Judith C. Ahronheim, Mark Siegler, Leon Kass, John Lantos, Robert A. Burt, Kathleen Foley, Richard Payne, Carlos Gomez, Thomas J. Krizek, Edmund D. Pellegrino, and Russell K. Portenoy
Anne Hudson Jones Augusto and Michaela Odone (Nick Nolte and Susan Sarandon) resolve to learn all they can about their son's illness. Lorenzo's Oil provides a case worth examining not only for its own story but also for what it reveals about a movie's ability to work on many levels at once and thereby transcend its own particularities to illuminate wider aspects of medical and cultural realities.
Charles E. Schwartz
Janice P. Dutcher
George Young
Norton J. Greenberger This Update addresses several of the ongoing debates in the gastroenterology literature. Topics discussed include esophageal disorders, acid peptic disorders, gastrointestinal effects of cyclooxygenase-2 inhibitors, and hepatobiliary disease. | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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