 |
 |
|
Home |
Current Issue |
Past Issues |
In the Clinic |
ACP Journal Club |
CME |
Collections |
Audio/Video |
Mobile |
Subscribe |
Tools |
Help |
ACP Online
|
|
Articles 
Francine Grodstein, JoAnn E. Manson, Graham A. Colditz, Walter C. Willett, Frank E. Speizer, and Meir J. Stampfer Postmenopausal hormone use appears to decrease risk for major coronary events in women without previous heart disease. Furthermore, 0.3 mg of oral conjugated estrogen daily is associated with a reduction similar to that seen with the standard dose of 0.625 mg. However, estrogen at daily doses of 0.625 mg or greater and in combination with progestin may increase risk for stroke.
George F. Sawaya, Deborah Grady, Karla Kerlikowske, June La Valleur, Vanessa M. Barnabei, Katherine Bass, Thomas E. Snyder, James H. Pickar, Sanjay K. Agarwal, Jeanne Mandelblatt for the Heart and Estrogen/progestin Replacement Study (HERS) Research Group Because of a poor positive predictive value, cervical smears should not be performed within 2 years of normal cytologic results in postmenopausal women. Therapy with oral estrogen plus progestin does not significantly affect the incidence of cytologic abnormalities.
Shreyasee Amin, Yuqing Zhang, Clark T. Sawin, Stephen R. Evans, Marian T. Hannan, Douglas P. Kiel, Peter W.F. Wilson, and David T. Felson In elderly men, hypogonadism related to aging has little influence on bone mineral density, but serum estradiol levels have a strong and positive association with this measure.
Brief Communications
John F. Reinus, Seth Persky, Jill S. Burkiewicz, David Quan, Nathan M. Bass, and Timothy J. Davern Patients receiving zafirlukast may develop severe liver injury and should be observed for signs and symptoms of hepatitis.
Steven J. Lester, Matthew Baggott, Susette Welm, Nelson B. Schiller, Reese T. Jones, Elyse Foster, and John Mendelson Modest oral doses of MDMA (the psychoactive stimulant commonly known as ecstasy) increase heart rate, blood pressure, and myocardial oxygen consumption in a magnitude similar to that seen with dobutamine, 20 to 40 µg/kg per minute. Unlike dobutamine, MDMA has no measurable inotropic effects.
Perspectives
Robert B. Couch Reducing influenza to a minor medical problem will require approval of the live attenuated vaccine, development of better inactivated vaccines, availability of better rapid diagnostic methods, additions to the current antiviral options, and optimal application of all available methods.
Editorials
Deborah Grady and Stephen B. Hulley Despite strong observational evidence from the Nurses' Health Study (including that reported by Grodstein and colleagues in this issue) and others, the disappointing results of three recent trials indicate that clinicians should not use hormone therapy for prevention of coronary disease until this practice is supported by evidence from randomized trials.
Ronald S. Swerdloff and Christina Wang In this issue, Amin and colleagues report a lack of relationship between serum levels of total testosterone and bone mineral density in older men. However, they found a strong positive correlation between serum estradiol level and bone mineral density. These data are of considerable interest and require careful interpretation because they may have implications for management of older men using androgen replacement treatment.
On Being a Doctor
Itzhak Kronzon The techniques of close-magic tricks and a procedure in the catheterization lab have some things in common.
Letters Management of Suspected Ventilator-Associated Pneumonia
Liver Disease and Home Parenteral Nutrition
Noncardiogenic Pulmonary Edema in Marathon Runners
Richard S. Rees
Jean-Pierre Raufman
Gina Rollins
Robert Fromm, Jr. and Kalpalatha Guntupalli The studies summarized in this Update illustrate how relatively simple ideas and solutions in the intensive care unit can reduce mortality and complication rates and save costs.
Ralph Gonzales and Merle A. Sande The authors describe recent developments in the pathophysiology, evaluation, and treatment of uncomplicated acute bronchitis and discuss the impact of efforts to reduce prescription of antibiotics for this illness. | ||||||||||||||||||||||||||||||||||||||||||||||||||
In this Issue
Articles
Previous Issue