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Articles 
Yasushi Shiratori, Fumio Imazeki, Mitsuhiko Moriyama, Michitami Yano, Yasuyuki Arakawa, Osamu Yokosuka, Tetsuo Kuroki, Shuhei Nishiguchi, Michio Sata, Gotarou Yamada, Shigetoshi Fujiyama, Haruhiko Yoshida, and Masao Omata In this cohort study of patients with chronic hepatitis C, regression of fibrosis was associated with sustained virologic response to interferon therapy.
Maryan Cavicchi, Philippe Beau, Pascal Crenn, Claude Degott, and Bernard Messing The prevalence of complicated liver disease related to home parenteral nutrition increased with longer duration of parenteral nutrition. This condition was one of the main causes of death in patients with permanent intestinal failure.
Vincent Mooser, Nicole Helbecque, Judit Miklossy, Santica M. Marcovina, Pascal Nicod, and Philippe Amouyel In this convenience sample, lipoprotein(a) was an additional risk factor for late-onset Alzheimer disease in carriers of the apolipoprotein E
Daniel Zambón, Joan Sabaté, Sonia Muñoz, Betina Campero, Elena Casals, Manuel Merlos, Juan C. Laguna, and Emilio Ros Previous studies have reported that walnuts decrease serum cholesterol levels in young men. In this study of men and women with polygenic hypercholesterolemia, substituting walnuts for part of the monounsaturated fat in a cholesterol-lowering Mediterranean diet further reduced total fat and low-density lipoprotein cholesterol levels.
Brief Communications
Steven H. Smoger, Toni L. Felice, and Goetz H. Kloecker According to this survey study, urinary incontinence is common among male veterans and affects all age groups. Despite the unfavorable effects of incontinence on quality of life, the men surveyed seldom discussed the problem with medical providers.
Christopher R. Cole, JoAnne M. Foody, Eugene H. Blackstone, and Michael S. Lauer Abnormal heart rate recovery after symptom-limited exercise is an important prognostic factor. This study found that even after submaximal exercise in patients in good cardiovascular health, abnormal heart rate recovery predicts death.
Updates
Lorne E. Goldman and Mark J. Eisenberg This review of the literature on identifying and managing patients in whom thrombolysis had failed after myocardial infarction pays particular attention to the noninvasive identification of reperfusion and the use of rescue percutaneous transluminal coronary angioplasty.
Reviews
Jerome Seidenfeld, David J. Samson, Vic Hasselblad, Naomi Aronson, Peter C. Albertsen, Charles L. Bennett, and Timothy J. Wilt In men with advanced prostate cancer, survival after therapy with a luteinizing hormone–releasing hormone (LHRH) agonist was found to be equivalent to survival after orchiectomy. Although patients prefer to avoid orchiectomy, it is unknown whether this procedure decreases quality of life. No evidence shows a difference in effectiveness or adverse effects among the LHRH agonists.
Perspectives
Stephen G. Post, Christina M. Puchalski, and David B. Larson The ethical aspects of physicians' attention to the spiritual and religious dimensions of their patients' experiences of illness require review and discussion. Should physicians discuss spiritual issues with their patients? What are the boundaries between physicians and patients regarding these issues? What are the boundaries between physicians and chaplains?
Editorials
David J. Vaughn After years of clinical investigation and experience, questions about the optimal hormonal therapy in men with advanced prostate cancer still remain. In this issue, Seidenfeld and colleagues present results of their meta-analysis on various forms of hormonal monotherapy. What other options are available for these patients?
On Being a Doctor
Thomas L. Petty The author's 12-year relationship with an elderly man with emphysema reaffirms his belief in house calls and the benefit of home care.
On Being a Patient
Michael C. Dohan The author recounts his long journey through bone marrow transplantation and recovery and the new insights he has gained about the doctor–patient relationship.
Letters Serum Uric Acid and Cardiovascular Disease Risk
Clinically Useful Problem Statement Systems
Pain Management in Patients with Advanced Cancer
Medical Management of Aldosterone-Producing Adenomas
Nasogastric Tubes Permit Reflux and Aspiration: Is There Any Evidence?
Whipple Endocarditis without Gastrointestinal Disease
Calcium Carbonate–Induced Hypothyroidism
Ischemic Colitis Associated with Factor V Leiden Mutation
Chemoembolization of Liver Metastases from Medullary Thyroid Carcinoma
Sumatriptan-Associated Mesenteric Ischemia
Congenital C2 (Type I) Deficiency Associated with Common Variable Immunodeficiency
Cerivastatin-Induced Rhabdomyolysis
Lamivudine-Associated Remission of Chronic Hepatitis Delta
Erin H. McLeary The Mütter Museum of the College of Physicians of Philadelphia is typical of the medical museums that were once found in almost all medical schools. Contemporary visitors to this and other medical museums can easily appreciate the museum's role in preserving artifacts for study, but the other two original functions of the museums—education and commemoration—may not be as apparent.
Frederic W. Platt
Marshall B. Kapp
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4 allele. However, lipoprotein(a) may protect against late-onset Alzheimer disease in noncarriers.