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Articles 
Kenneth J. Smith and Mark S. Roberts In an analysis biased against use of sildenafil, the cost-effectiveness of sildenafil treatment for erectile dysfunction compared favorably with that of accepted therapies for other medical conditions.
Douglas S. Bell, Gregg C. Fonarow, Ron D. Hays, and Carol M. Mangione On-line tutorials for physicians may improve learning efficiency and satisfaction more than print materials do, but one self-study exposure may be insufficient for long-term knowledge retention.
Barbara White, Wendy C. Moore, Fredrick M. Wigley, Hui Qing Xiao, and Robert A. Wise The presence of lung inflammation identified patients with scleroderma who are more likely to have worsening lung function. Survival and lung function outcomes are improved in patients with alveolitis who receive cyclophosphamide.
Brief Communications
Todd B. Seto, Deborah A. Taira, Ronna Berezin, Manish S. Chauhan, Donald E. Cutlip, Kalon K.L. Ho, Richard E. Kuntz, and David J. Cohen Elderly patients who were selected for participation in a trial of percutaneous coronary intervention had substantial improvements in health-related quality of life after this intervention that were similar to improvements in younger patients.
Anthony E.T. Yeo, Akihiro Matsumoto, Michie Hisada, James W. Shih, Harvey J. Alter, James J. Goedert for the Multicenter Hemophilia Cohort Study* Hemophilic, HIV-positive patients with past or current hepatitis G virus infection had higher CD4+ lymphocyte counts and better AIDS-free survival rates. The mechanism of this association is unknown.
Academia and Clinic
Peter J. Neumann, Patricia W. Stone, Richard H. Chapman, Eileen A. Sandberg, and Chaim M. Bell Cost-utility analysis is an active and evolving field, but more consistency and clarity in reporting are needed. Better peer review and independent, third-party audits may help in this regard.
Reviews
Karen Rosene-Montella, Erin Keely, Steven A. Laifer, and Richard V. Lee This article reviews the definitions and scope of infertility, the interventions used for treatment of infertility, the medical complications of these interventions, the potential risks of fertility treatment in women unable to conceive spontaneously, and important issues for preconception counseling.
Abroad
Barbara L. Herwaldt, Kathleen R. de Arroyave, Jacquelin M. Roberts, and Dennis D. Juranek Mild to moderate diarrheal disease continued to occur throughout Peace Corps service but decreased in incidence as length of stay increased. Various dietary behaviors increased the risk for diarrheal illness, suggesting that avoidance of potentially risky foods and beverages is actually beneficial.
Perspectives
Rogerio A. Lobo and Enrico Carmina The polycystic ovary syndrome (PCOS) is known to be associated with reproductive morbidity and increased risk for endometrial cancer. Diagnosis is especially important because PCOS is now thought to increase metabolic and cardiovascular risks.
Editorials
Michael R. McGarvey Smith and colleagues' cost-effectiveness analysis of sildenafil (Viagra) raises a fundamental and challenging issue associated with this therapeutic advance: Should health insurance pay for the treatment of erectile dysfunction at all?
Frank Davidoff and Valerie Florance It is unacceptable in this "information age" for medical information to remain in its current neglected and disorderly state. The concept of the informationist—a professional who will retrieve, synthesize, and present medical information—is an idea whose time has come.
On Being a Doctor
Richard G. Druss I had no interest in science whatsoever until my junior year in high school, when I met Dr. Elizabeth Helly. She appeared to have but two interests: her students and mathematics.
On Being a Patient
Penelope J. Tipton I was at the time a college student in Boston. Abortion was illegal. "Potassium permanganate can induce a spontaneous abortion. It is," my chemistry lab partner whispered, "an abortifacient."
Letters Management of Fibromyalgia
Time and Medicine
Auscultation through a Shirt
Hemolytic Uremic Syndrome in a Patient Treated with Clopidogrel
Cholangiocarcinoma and AIDS-Related Sclerosing Cholangitis
The Cadaveric Option
Isotretinoin in Respiratory Papillomatosis
Interruption of the Inferior Vena Cava in a Patient with Hirschsprung Disease
Eugenic Sterilization and a Nazi Analogy
Richard Lower: Anatomist and Physiologist
Epidemiologic Relation between HIV and Invasive Pneumococcal Disease in San Francisco County, California
Chronic Dizziness among Older Adults
Cocaine-Induced Acute Cytologic Hepatitis in HIV-Infected Patients with Nonactive Viral Hepatitis
Parvovirus B19–Related Anemia in an HIV-Infected Patient: Rapid Control after Production of Neutralizing Antibodies during Highly Active Antiretroviral Therapy
Correction: Misaligned Table
Correction: End-of-Life Care Paper
Philippe O. Szapary
Philippe O. Szapary
Allen D. Soffer
Miriam Shuchman
Aaron Levin
Ruzha P. Cleaveland
Stan Schuman
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