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Articles 
John A. Heit, C. Gregory Elliott, Arthur A. Trowbridge, Bernard F. Morrey, Michael Gent, Jack Hirsh for the Ardeparin Arthroplasty Study Group* Among patients who had total knee or total hip replacement and received 4 to 10 days of postoperative ardeparin prophylaxis, the cumulative incidence of symptomatic venous thromboembolism or death after hospital discharge was not significantly reduced by extended out-of hospital ardeparin prophylaxis.
Tauqir Y. Goraya, Steven J. Jacobsen, Patricia A. Pellikka, Todd D. Miller, Akbar Khan, Susan A. Weston, Bernard J. Gersh, and Véronique L. Roger In elderly patients, treadmill exercise testing provided prognostic information that was incremental to clinical data. After adjustment for clinical factors, workload was the only treadmill exercise testing variable strongly associated with outcome, and its prognostic effect was of the same magnitude in elderly and younger persons.
James R. Seibold, Joseph H. Korn, Robert Simms, Phillip J. Clements, Larry W. Moreland, Maureen D. Mayes, Daniel E. Furst, Naomi Rothfield, Virginia Steen, Michael Weisman, David Collier, Fredrick M. Wigley, Peter A. Merkel, Mary Ellen Csuka, Vivien Hsu, Susan Rocco, Mark Erikson, John Hannigan, W. Scott Harkonen, and Martin E. Sanders Twenty-four weeks of recombinant human relaxin therapy was associated with reduced skin thickening, improved mobility, and improved function in patients with moderate to severe diffuse scleroderma.
Brief Communications
Iris Baumgartner, Guenter Rauh, Ann Pieczek, Debra Wuensch, Meredith Magner, Marianne Kearney, Robert Schainfeld, and Jeffrey M. Isner Vascular endothelial growth factor (VEGF) may enhance vascular permeability in humans. In this study, 34% of patients undergoing VEGF gene transfer developed lower-extremity edema. This condition responded to oral diuretic therapy and did not seem to be associated with serious sequelae.
Rose-Irene Verdier, Daniel W. Fitzgerald, Warren D. Johnson, Jr., and Jean William Pape A 1-week course of trimethoprim–sulfamethoxazole was effective in HIV-infected patients with cyclosporiasis or isosporiasis. Although ciprofloxacin was not as effective, it is acceptable for patients who cannot tolerate trimethoprim–sulfamethoxazole.
Academia and Clinic
Phyllis L. Carr, Arlene S. Ash, Robert H. Friedman, Laura Szalacha, Rosalind C. Barnett, Anita Palepu, and Mark M. Moskowitz Despite substantial increases in the number of female faculty, reports of gender-based discrimination and sexual harassment remain common.
Reviews
Jeffrey G. Wiese, Michael G. Shlipak, and Warren S. Browner Alcohol hangover, a common disorder, has substantial morbidity and societal cost. Appropriate management may relieve symptoms in many patients.
John A. Astin, Elaine Harkness, and Edzard Ernst The methodologic limitations of several studies make it difficult to draw definitive conclusions about the efficacy of distant healing (prayer, mental healing, Therapeutic Touch, or spiritual healing). However, given that approximately 57% of 23 trials showed a positive treatment effect, the issue thus far merits further study.
Perspectives
Jack Coulehan In 1996, Port Arthur, Tasmania, was the site of the worst mass murder in Australian history. This paper highlights the contrast between the Australian response to this tragedy and how U.S. society responds to similar violence.
Editorials
Bruce L. Davidson and Anthonie W.A. Lensing In this issue, Heit and colleagues report on their important study of prolonged ardeparin sodium prophylaxis against venous thromboembolism after joint replacement surgery. What additional guidance for assessing the value of this treatment can be gained from this report?
Oliver W. Press The path leading from the bench to the clinic has been more tortuous than initially envisioned, but it now appears certain that immunotherapeutic approaches will play an expanding role in the management of lymphomas and other malignant conditions.
On Being a Doctor
Danielle Ofri The omniscience blithely promised by my residency training is easily deflated by the unadorned actualities of life. Where did I get the absurd notion that I might be a healer?
Letters Blood Cultures Drawn from Indwelling Central Venous Catheters
Name-Based Surveillance for HIV-Infected Persons
Physical Therapy and Exercise in Osteoarthritis of the Knee
Optimal Acid Suppression Therapy in Critically Ill Patients
Marked Peripheral Edema Associated with Montelukast and Prednisone
Hepatopulmonary Syndrome in Noncirrhotic Portal Hypertension
Control Group Selection Is an Important but Neglected Issue in Studies of Antibiotic Resistance
Thrombocytopenia after Iron Dextran Administration in a Patient with Severe Iron Deficiency Anemia
John F. Steiner and Mark A. Earnest Terms such as "compliance" and "adherence" are too facile to describe complex behavioral issues in medicine. They should be replaced by a language that is less succinct but richer in its description and analysis of human behavior.
William Amend
Richard N. Channick
Leonard E. Braitman
Nelson G. Richards
Lori Levy
Margaret Divish
Anne Caston
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