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Articles 
Nancy L. Keating, Paul D. Cleary, Alice S. Rossi, Alan M. Zaslavsky, and John Z. Ayanian Sociodemographic factors, such as region and education, may be more strongly associated with use of hormone replacement therapy than are clinical factors, such as risk for cardiovascular disease.
Clemens von Schacky, Peter Angerer, Wolfgang Kothny, Karl Theisen, and Harald Mudra Dietary intake of
Kenneth E. Covinsky, Eva Kahana, Marshall H. Chin, Robert M. Palmer, Richard H. Fortinsky, and C. Seth Landefeld Depressive symptoms are associated with long-term mortality in older patients hospitalized with medical illnesses. This association is not fully explained by greater levels of comorbid illness, functional impairment, and cognitive impairment in patients with more symptoms of depression.
Veronica Miller, Amanda Mocroft, Peter Reiss, Christine Katlama, Anthony I. Papadopoulos, Terese Katzenstein, Jan van Lunzen, Francisco Antunes, Andrew N. Phillips, Jens D. Lundgren for the EuroSIDA Study Group* Increases in CD4 counts from very low levels to at least 200 cells/mm3 are associated with a reduced rate of disease progression. However, a previously low CD4 cell count nadir remains associated with a moderately high risk for disease progression among patients with CD4 cell counts of at least 200 cells/mm3.
Brief Communications
Olli T. Raitakari, Mark R. Adams, Robyn J. McCredie, Kaye A. Griffiths, and David S. Celermajer In healthy young adults, arterial endothelial dysfunction related to passive smoking seems to be partially reversible.
Eduardo R. Locatelli, Jacob P. Varghese, Ashfaq Shuaib, and Samuel J. Potolicchio This report describes three patients with asystole or bradycardia associated with complex partial seizures and reviews the relevant literature.
Updates
Karl A. Sporer This Update reviews the clinically relevant pharmacology of heroin and naloxone, the epidemiology of fatal and nonfatal heroin overdose, the clinical diagnosis of heroin overdose, appropriate treatment, complications, and prevention strategies.
NIH Conferences
Stephen E. Straus, Michael Sneller, Michael J. Lenardo, Jennifer M. Puck, and Warren Strober The autoimmune lymphoproliferative syndrome is a recently defined illness that arises in early childhood and is associated with prominent nonmalignant lymphadenopathy, hepatosplenomegaly, and autoimmune manifestations. This syndrome affords novel insights into the mechanisms that regulate lymphocyte homeostasis and underlie the development of autoimmunity.
Editorials
Jennifer Daley The results of Keating and colleagues' study, reported in this issue, suggest that we may have many more questions to ask and answer about our female patients and how we collaborate with them to find out whether they should use hormone replacement therapy.
Steven N. Goodman As highlighted by Steiner's paper in this issue, evidence-based medicine must grapple with the fact that in the individual patient, one of its pillars—probability—is ambiguous and elusive, no matter how we choose to communicate it.
Laura A. Siminoff and Robert Arnold The shortage of transplantable organs hits the African-American community disproportionately hard. What is responsible for this shortage, and what can be done about it?
On Being a Doctor
Bhuvana Chandra He greeted me as he always did, hands folded weakly together in the gesture of respect that is ubiquitous in India.
Letters Features and Outcomes of Classic Heat Stroke
Flock Worker's Lung
Secrecy in Science: The Flock Worker's Lung Investigation
Increasing Stair Use
Skin Biopsies, Cutaneous Disease, and Primary Care
John F. Steiner As physicians, we need to become bilingual—we must speak the language of populations as well as the language of individual patients. If we are fluent in both languages, we remind ourselves that we offer our patients choices, not treatments, and we remind our patients that whatever their treatment choices, the outcomes of health care are uncertain.
Kenneth R. Hande
Edward J. Huth
Matthew Rusk
Rashid L. Bashshur
Jennifer Best
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-3 fatty acids modestly mitigates the course of coronary atherosclerosis in humans.