Recent Developments in Pulmonary Edema
- EDWARD D. CRANDALL, Ph.D., M.D.;
- NORMAN C. STAUB, M.D.;
- HOWARD S. GOLDBERG, M.D.; and
- RICHARD M. EFFROS, M.D.
Abstract
Research on lung fluid balance and pulmonary edema has increased during the last decade. New approaches have led to insights into the role of each component of the alveolar-capillary barrier. The capillary endothelium is the first line of defense against lung fluid accumulation. The interstitium may play a more important role in lung fluid balance than previously appreciated. Active and passive transport properties of alveolar epithelium may be important in the pathogenesis and resolution of alveolar edema. New methods for the determination of epithelial permeability and lung water are being evaluated. The developments reviewed here may have an impact on the institution of new diagnostic and therapeutic approaches to pulmonary edema during the next decade.
Article and Author Information
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▸An edited summary of an Interdepartmental Conference arranged by the Department of Medicine of the UCLA School of Medicine; Los Angeles, California.
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▸Authors who wish to cite a section of this conference and specifically indicate its author can use this example for the form of the reference:
STAUB NC. Role of the endothelium in lung fluid balance, pp. 808-11. In: CRANDALL ED, moderator. Recent developments in pulmonary edema. Ann Intern Med. 1983;99:808-22.
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Grant support: by grants HL26223 and HL18606 from the U. S. Public Health Service; and by grant IG-738 from the Greater Los Angeles Affiliate of the American Heart Association. Dr. Goldberg's research supported by funds from the Irvine Foundation, Sidney Stern Memorial Trust, and the Herzog Family Trust.
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▸Requests for reprints should be addressed to Edward D. Crandall, Ph.D., M.D.; Department of Medicine, Division of Pulmonary Disease, UCLA School of Medicine; Los Angeles, CA 90024.
- ©1983 American College of Physicians
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