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Cytomegalovirus Infections in Homosexual Men
An Epidemiological Study
- LAWRENCE MINTZ, M.D.;
- W. LAWRENCE DREW, M.D., Ph.D.;
- RICHARD C. MINER, B.A.; and
- ERWIN H. BRAFF, M.D.
Abstract
Levels of cytomegalovirus antibody (IgG and IgM) were measured and urine viral cultures were done in 237 homosexual men over a mean period of 14.1 months. The initial prevalence of cytomegalovirus IgG antibody was 86.9%. By the 9th month of follow-up, 71% of serosusceptible men had become infected with cytomegalovirus. During the study period cytomegaloviruria was noted in 32% of seropositive men. Cytomegalovirus IgM antibody was intermittently present in the serum of 95% of IgG-seropositive men, suggesting that frequent reactivation of latent infection or reexposure to exogenous virus had occurred. Of seven sexual practices investigated, only passive anal-genital intercourse correlated with the acquisition of cytomegalovirus infection (p =0.008).
Article and Author Information
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▸From the Biskind Research Laboratory, Departments of Pathology and Laboratory Medicine and Medicine, Mount Zion Hospital and Medical Center; and the San Francisco Department of Public Health; San Francisco, California.
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Grant support: in part by grants from the John A. Kerner Foundation; the Ernest H. Rosenbaum Cancer Research Fund; and the Alan B. Glassberg Cancer Research Fund, Mount Zion Hospital and Medical Center.
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▸Requests for reprints should be addressed to Lawrence Mintz, M.D.; Department of Pathology and Laboratory Medicine; Mount Zion Hospital and Medical Center; 1600 Divisadero Street; San Francisco, CA 94115.
- © 1983 American College of Physicians
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