Estrogen Replacement Therapy: Indications and Complications

  1. HOWARD L. JUDD, M.D.;
  2. DAVID R. MELDRUM, M.D.;
  3. LEONARD J. DEFTOS, M.D.; and
  4. BRIAN E. HENDERSON, M.D.
  1. Los Angeles and La Jolla, California

    Abstract

    Estrogen replacement therapy is one of the most controversial issues in the field of reproductive medicine. Indications for its use include hot flashes, vaginal atrophy, and risk of osteoporosis. Risk of heart disease may also be an indication but this use has not been firmly established. The role of estrogen replacement therapy in aging changes of skin needs clarification. Complications of therapy include endometrial cancer, breast cancer, hypertension, hyperlipidemia, and gallbladder disease. The last three complications presumably result from hepatic actions of estrogen replacement therapy.

    Article and Author Information

    • ▸An edited transcription of an Interdepartmental Conference arranged by the Department of Medicine of the UCLA School of Medicine, Los Angeles, California.

    • ▸Authors who wish to cite a section of this conference and specifically indicate its author can use this example of the form of the reference:

      MELDRUM DR. Hot flashes, pp. 195-7. In: JUDD HL, moderator. Estrogen replacement therapy: indications and complications. Ann Intern Med. 1983;98:195-205.

    • Grant support: by grants CA 23093, RR 865, 2 PO1 CA 17054, and AM 15888, National Institutes of Health; and grants from the American Cancer Society and the Veterans Administration.

    • ▸Requests for reprints should be addressed to Howard L. Judd, M.D.; Department of Obstetrics and Gynecology, UCLA School of Medicine; Los Angeles, CA 90024.

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    1. Ann Intern Med February 1, 1983 vol. 98 no. 2 195-205
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