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The Cimetidine-Lidocaine Interaction
- ALBERT B. KNAPP, M.D.;
- WILLIAM MAGUIRE, M.D., Ph.D.;
- GAD KEREN, M.D.;
- ARTHUR KARMEN, M.D.;
- BARRIE LEVITT, M.D.;
- DENNIS S. MIURA, M.D., Ph.D.; and
- JOHN C. SOMBERG, M.D.
Excerpt
Lidocaine is a widely used antiarrhythmic agent whose plasma clearance varies with changes in hepatic blood flow. Cimetidine, an H2-receptor antagonist, has been shown to decrease hepatic blood flow. To ascertain whether cimetidine affected serum lidocaine concentration, we studied 21 patients receiving lidocaine infusions and divided them into two groups. Fifteen patients received cimetidine, 300 mg every 6 hours, in addition to lidocaine; six patients received only lidocaine. In 14 of the 15 patients receiving both lidocaine and cimetidine, a rise in serum lidocaine levels was seen, whereas no change was noted in the control group. Six of the 15
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgments
ACKNOWLEDGMENTS: The authors thank the housestaff of the Albert Einstein College of Medicine and the nurses of the coronary and intensive care units of the Hospital of the Albert Einstein College of Medicine for their assistance, and Ms. K. Lisa Garrison for her help in preparing the manuscript.
Article and Author Information
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▸From the Division of Cardiology, Department of Medicine, and the Division of Clinical Pharmacology, Department of Molecular Pharmacology, Albert Einstein College of Medicine; Bronx, New York.
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Grant support: Dr. Knapp is a fellow in Gastroenterology at Brigham and Women's Hospital, Boston, Massachusetts; Dr. Somberg is an Established Investigator of the American Heart Association.
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▸Requests for reprints should be addressed to John C. Somberg, M.D.; Albert Einstein College of Medicine, 1300 Morris Park Avenue; Bronx, NY 10461.
- © 1983 American College of Physicians
