Elevated Serum Free Thyroxine by Thyroxine Analog Radioimmunoassays in Euthyroid Patients with Familial Dysalbuminemic Hyperthyroxinemia
- RAJATA RAJATANAVIN, M.D.;
- LAWRENCE FOURNIER, A.A.;
- DIANE DeCOSIMO, M.D.;
- CYNTHIA ABREAU, B.S.; and
- LEWIS E. BRAVERMAN, M.D.
Excerpt
Various radioimmunoassay kits have been developed for measuring the serum free thyroxine (T4) concentration. Values for free T4 obtained with these kits correlate well with values obtained by the more cumbersome and time-consuming method of equilibrium dialysis in patients with thyroid dysfunction and abnormalities in the serum thyroxine-binding globulin concentration (1, 2). However, when some of these kits are used to assess serum free T4 in euthyroid patients with nonthyroidal illnesses, the values may be lower than those obtained with equilibrium dialysis (2-5). These discrepancies may limit the clinical usefulness of these methods in ill, euthyroid patients.
Familial dysalbuminemic hyperthyroxinemia
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgments
ACKNOWLEDGMENTS: Grant support: in part by grant AM 18919 from the National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland.
Article and Author Information
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▸Requests for reprints should be addressed to Lewis E. Braverman, M.D.; University of Massachusetts Medical School, 55 Lake Avenue North; Worcester, MA 01605.
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