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Drugs Five Years Later
Etidronate Disodium in the Treatment of Paget's Disease of Bone
Abstract
Control of Paget's disease of bone has been possible through treatment with agents that decrease bone resorption; calcitonins, diphosphonates, and mithramycin. The pagetic lesion is not, however, cured. Etidronate disodium is one of the diphosphonates. The clinical improvement attained with this drug has to be set against adverse effects, of which pain is probably the most bothersome in practice. Clinical remission can last as long as 2 years after treatment is stopped.
Article and Author Information
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▸From the Department of Medicine, Harvard Medical School, and the Arthritis Unit, Medical Services, Massachusetts General Hospital; Boston, Massachusetts.
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Grant support: by grants AM-03564 and AM-04501, U.S. Public Health Service.
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▸Requests for reprints should be addressed to Stephen M. Krane, M.D.; Massachusetts General Hospital; Boston, MA 02114.
- ©1982 American College of Physicians
