RSS Feeds
Hemolytic Anemia Induced by Dapsone Transmitted Through Breast Milk
- STEPHEN W. SANDERS, Pharm.D.;
- JOHN J. ZONE, M.D.;
- RODGER L. FOLTZ, Ph.D.;
- KEITH G. TOLMAN, M.D.; and
- DOUGLAS E. ROLLINS, M.D., Ph.D.
Excerpt
Dapsone (4,4′-diaminodiphenyl sulphone) is used to treat several dermatologie disorders (1) including dermatitis herpetiformis. Due to the chronicity of dermatitis herpetiformis and its frequent onset from age 20 to 40 years, therapy with dapsone may coincide with pregnancy and lactation. We describe an infant who had significant serum concentrations of dapsone and its primary metabolite, monoacetyldapsone, after ingesting breast milk containing dapsone. Both the mother and infant had compensated hemolytic anemia.
Dapsone and monoacetyldapsone were analyzed by high pressure liquid chromatography using a modification of the method of Carr and associates (2). Recrystallized 3,3′-diaminodiphenylsulfone (Pfaltz & Bauer, Inc., Stamford, Connecticut)
This 100-word excerpt has been provided in the absence of an abstract.
Article and Author Information
-
Dr. Sanders is a Burroughs Wellcome Fellow in Clinical Pharmacy.
-
Grant support: in part by Public Health Services research grant RR-64, Division of Research Resources; and grant 1R01AM 28412-01, National Institutes of Health.
-
▸Requests from reprints should be addressed to Douglas E. Rollins, M.D., Ph.D. Department of Internal Medicine, University Medical Center, 50 North Medical Drive; Salt Lake City, UT 84132.
