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Hemoperfusion for Phenylbutazone Poisoning
- WILLIAM G. BERLINGER, M.D.;
- REYNOLD SPECTOR, M.D.;
- MICHAEL J. FLANIGAN, M.D.;
- GEORGE F. JOHNSON, Ph.D.; and
- MICHAEL R. GROH, B.S.
Excerpt
An overdose with phenylbutazone causes a syndrome that may include seizures, coma, and metabolic acidosis (1). Serious tissue damage such as hepatic necrosis, renal failure, cardiovascular collapse, and death, may occur (1). We report a case of a comatose, hypotensive patient who had ingested at least 4 g of phenylbutazone. Because of the long half-life of phenylbutazone (approximately 3 days) and the potential for significant tissue damage, we treated this patient with hemoperfusion.
A 37-year-old woman with rheumatoid arthritis was transferred from another hospital to the University of Iowa Hospital in a deep coma 36 hours after a massive ingestion of
This 100-word excerpt has been provided in the absence of an abstract.
Acknowledgments
The authors thank Dr. Richard M. Freeman for encouragement and support and Susan G. Heitshusen and Mark Edler for aid in preparing the report.
Article and Author Information
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▸Requests for reprints should be addressed to Reynold Spector, M.D.; University of Iowa Hospitals and Clinics, Department of Medicine, Iowa City, IA 52242.
