Acute Myelocytic Leukemia in Two Brothers with Polyposis Coli and Carcinoma of the Colon

  1. MORTIMER S. GREENBERG, M.D.;
  2. KENNETH C. ANDERSON, M.D.;
  3. DAVID J. MARCHETTO, M.S.; and
  4. FREDERICK P. LI, M.D.
  1. Cambridge and Boston, Massachusetts

    Abstract

    Two brothers developed multiple adenomatous polyps of the colon and colonic adenocarcinoma, the classic features of familial polyposis coli. Both also developed acute myelocytic leukemia. This constellation of neoplasms is distinct from other genetic syndromes that feature polyposis coli. The parents of the brothers are first cousins, suggesting autosomal recessive inheritance of these multiple neoplasms. Autosomal dominant or X-linked transmission is also possible and should be evaluated in other affected families.

    Article and Author Information

    • ▸From the Mount Auburn Hospital, Cambridge, Massachusetts; and the Divisions of Medical Oncology, and Biostatistics and Epidemiology, Sidney Farber Cancer Institute, and Clinical Epidemiology Branch, National Cancer Institute; Boston, Massachusetts.

    • ▸Requests for reprints should be addressed to Mortimer S. Greenberg, M.D.; Mount Auburn Hospital, 416 Doctors' Office Building, 300 Mount Auburn Street; Cambridge, MA 02138.

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    1. Ann Intern Med December 1, 1981 vol. 95 no. 6 702-703
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