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Serum Angiotensin-Converting Enzyme and Lysozyme in Granulomatous Diseases of Unknown Cause
- PAUL KATZ, M.D.;
- ANTHONY S. FAUCI, M.D.;
- HENRY YEAGER, Jr., M.D.; and
- BERNARD M. REEN, M.D.
- National Institute of Allergy and Infectious Diseases; Bethesda, Maryland Georgetown University School of Medicine; Washington, D.C.
Excerpt
Over the past several years, attempts to develop specific serologic tests for diagnosing sarcoidosis have been the focus of intense investigation. That serum levels of angiotensin-converting enzyme (1) and lysozyme (2) are elevated in this disorder has been established, although the diagnostic value of these tests has been recently questioned (3, 4). The present study was undertaken to ascertain the levels of serum angiotensin-converting enzyme and lysozyme in noninfectious granulomatous disorders of unknown cause other than sarcoidosis.
Serum samples from eight patients with granulomatous hepatitis, nine with Wegener's granulomatosis, three with lymphomatoid granulomatosis, and four with midline granuloma were stored
This 100-word excerpt has been provided in the absence of an abstract.
Article and Author Information
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The authors thank Drs. James Cassait and Donna K.F. Chandler for their guidance in setting up the assays described in this paper.
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Grant support: to Dr. Reen by a summer fellowship, Biomedical Research Support grant RR5360, from the Division of Research Resources, National Institutes of Health.
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▸Requests for reprints should be addressed to Paul Katz, M.D.; Building 10, Room 11B-13, National Institutes of Health; Bethesda, MD 20205.
