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Reversal of Long-Standing Renal Insufficiency by Captopril in a Patient with Relapsing Hemolytic Uremic Syndrome Due to an Oral Contraceptive
- STEVEN J. HOORNTJE, M.D.;
- ERIK J. L. PRINS, M.D.;
- ANDRIES J. SMIT, M.D.; and
- AB J. M. DONKER, M.D.
Excerpt
Various diseases, including the hemolytic uremic syndrome, produce renal functional changes by compromising renal circulation. Narrowing of the arteriolar lumen can lead to hypertension in a manner analogous to the Goldblatt mechanism (1). This condition may be managed successfully by blockade of the renin-angiotensin system (2).
We report reversal of hypertension and renal failure by captopril in a patient with the hemolytic uremic syndrome. A second attack occurred during captopril treatment shortly after the patient accidentally reinstituted use of the same oral contraceptive she had used before the first attack.
A 17-year old woman was admitted in 1977 because of
This 100-word excerpt has been provided in the absence of an abstract.
Article and Author Information
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▸Requests for reprints should be addressed to Steven J. Hoorntje, M.D.; Oostersingel 59, 9713 EZ Groningen; Groningen, the Netherlands.
