Combined Idiopathic Neutropenia and Thrombocytopenia

Evidence for an Immune Basis for the Syndrome

  1. CHARLES A. LINKER, M.D.;
  2. SAMUEL R. NEWCOM, M.D.;
  3. CLAES M. NILSSON, M.D.;
  4. JEFFREY L. WOLF, M.D.; and
  5. MARC A. SHUMAN, M.D.
  1. San Francisco, California

    Abstract

    We report a case of combined idiopathic immune neutropenia and immune thrombocytopenia (thromboneutropenia). Therapy with prednisone was ineffective. Treatment with vincristine raised the patient's platelet count but did not increase the neutrophil count. Splenectomy led to a prompt complete remission. Using radioimmunologic techniques, we have shown both antiplatelet and antineutrophil antibodies and have shown the disappearance of these antibodies after successful treatment.

    Article and Author Information

    • ▸From the Division of Hematology, Department of Medicine, University of California; San Francisco, California.

    • ▸Requests for reprints should be addressed to Charles A. Linker, M.D.; Cancer Research Institute—1282M, University of California; San Francisco, CA 94143.

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    This Article

    1. Ann Intern Med November 1, 1980 vol. 93 no. 5 704-707
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