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Effects of Quinidine on Serum Digoxin Concentration
A Prospective Study
- DENNIS R. MUNGALL, Pharm. D.;
- ROBERT P. ROBICHAUX, M.D.;
- WESLEY PERRY, R.N., M.S.N.;
- JOHNNY W. SCOTT, Ph.D., M.D.;
- ANDREW ROBINSON, Ph.D.;
- TIM BURELLE, Pharm. D.; and
- DAVID HURST, Ph.D.
Abstract
Results of studies of 15 adults placed on quinidine therapy after their serum digoxin concentrations were stabilized showed significantly increased digoxin concentrations. The average digoxin concentration before quinidine therapy was 0.75 ± 0.28 ng/mL and after 4 days of quinidine therapy was 1.41 ± 0.43 ng/mL. During this period, the renal clearance of digoxin decreased from 53.4 ± 21 mL/min · 1.73 m2 to 35.3 ± 12.6 mL/min · 1.73 m2. No significant decrease in creatinine clearance occurred. A significant correlation was found between the individual rise in serum digoxin concentrations and the rise in serum quinidine concentrations. These results suggest that serum digoxin concentration should be monitored closely for at least the first 4 days of quinidine therapy.
Article and Author Information
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▸From the Department of Clinical Pharmacy, Samford University School of Pharmacy, the Division of Cardiology, University of Alabama School of Medicine, and the Departments of Pharmacy, Nuclear Medicine, and Clinical Laboratories, Birmingham Veterans Administration Hospital; Birmingham, Alabama.
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Grant support: by a grant from Roche Laboratories, Division of Hoffman LaRoche, Inc. , and by Samford University Research Fund grants 75 and 77 from Samford University.
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▸Requests for reprints should be addressed to Dennis Mungall, Pharm. D.; 800 Lakeshore Drive, Samford University; Birmingham, AL 35209.
- © 1980 American College of Physicians
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