A Case of Guillain-Barré Syndrome with Immunologic Abnormalities

  1. CHRISTOPHER J. FROELICH, M.D.;
  2. ROBERT P. SEARLES, M.D.;
  3. LARRY E. DAVIS, M.D.; and
  4. JAMES S. GOODWIN, M.D.
  1. Albuquerque, New Mexico

    Abstract

    Guillain-Barré syndrome and the nephrotic syndrome developed in a patient simultaneously. Analysis of renal biopsy by light, immunofluorescent, and electron microscopy showed lipoid nephrosis. T-cell lymphocytopenia, lymphocytotoxic antibodies, depressed lymphocyte mitogenesis, and anergy also complicated the illness. The immunologic abnormalities resolved when the polyradiculoneuritis and lipoid nephrosis remitted. This previously undescribed association illustrates the occurrence of two postulated cell-mediated autoimmune disorders despite the presence of depressed cell-mediated immunity.

    Article and Author Information

    • ▸From the Departments of Medicine and Neurology, University of New Mexico School of Medicine and Albuquerque Veterans Admistration Hospital Lovelace Medical Center; Albuquerque, New Mexico.

    • Grant support: Dr. Searles is a Postdoctoral Research Fellow of the Arthritis Foundation.

    • ▸Requests for reprints should be addressed to Christopher J. Froelich, M.D.; Department of Medicine, Bernalillo County Medical Center, 2211 Lomas Boulevard NE; Albuquerque, NM 87131.

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    1. Ann Intern Med October 1, 1980 vol. 93 no. 4 563-565
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