Drug Therapy in Renal Failure: Dosing Guidelines for Adults

Part I: Antimicrobial Agents, Analgesics

  1. WILLIAM M. BENNETT, M.D.;
  2. RICHARD S. MUTHER, M.D.;
  3. RICHARD A. PARKER, M.D.;
  4. PETER FEIG, M.D.;
  5. GAIL MORRISON, M.D.;
  6. THOMAS A. GOLPER, M.D.; and
  7. IRWIN SINGER, M.D.
  1. Portland, Oregon; Philadelphia, Pennsylvania; and Farmington, Connecticut

    Abstract

    Data are presented in tabular form that provide guidelines for drug use in adult patients with renal insufficiency. The data are derived from the current medical literature. If specific information about a drug is unavailable or conflicting, emphasis is given to normal pharmacokinetic variables in arriving at recommendations for therapy. Nephrotoxicity or adverse effects in patients with renal disease are noted and adjustments for dialysis suggested.

    Article and Author Information

    • ▸From the Division of Nephrology, Department of Medicine, University of Oregon Health Sciences Center and Veterans Administration Hospital, Portland, Oregon; the Renal-Electrolyte Section, Department of Medicine, University of Pennsylvania School of Medicine and Veterans Administration Hospital, Philadelphia, Pennsylvania; and the Division of Nephrology, University of Connecticut School of Medicine, Farmington, Connecticut.

    • ▸Reprints of the combined Parts I and II of this article are available upon request from William M. Bennett, M.D.; Division of Nephrology, University of Oregon Health Sciences Center, 3181 Southwest Sam Jackson Park Road; Portland, OR 97201.

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    1. Ann Intern Med July 1, 1980 vol. 93 no. 1 Part 1 62-89
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