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Tumor-Associated Nephrogenic Diabetes Insipidus
- JOSHUA FEIBUSCH, M.D.;
- JOSE L. BARBOSA-SALDIVAR, M.D.;
- ROBERT S. BERNSTEIN, M.D.; and
- GARY L. ROBERTSON, M.D.
- Medical Service, Divisions of Gastroenterology and Metabolism, St. Luke's Hospital Center, and the Department of Medicine, Columbia University College of Physicians and Surgeons; New York, New York
- Indiana University Medical Center and Veterans Administration Hospital; Indianapolis, Indiana
Excerpt
Distant effects of benign or malignant tumors, mediated by humoral factors, are well known in the medical literature. Among these, the syndrome of inappropriate antidiuretic hormone secretion is frequently seen in malignant tumors. The opposite situation, that is, nephrogenic diabetes insipidus, or resistance to endogenous antidiuretic hormone, has never been described in association with a tumor. We report here what we believe to be the first such case.
A 47-year-old Hispanic man was admitted to St. Luke's Hospital Center in November 1977. The patient was well until January 1974, when he was first hospitalized for resection of an obstructing ileal
