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Growth Factors
- DAVID W. GOLDE, M.D.;
- HARVEY R. HERSCHMAN, Ph.D.;
- ALDONS J. LUSIS, Ph.D.; and
- JEROME E. GROOPMAN, M.D.
Abstract
Humoral regulation of somatic and hematopoietic cell growth has been intensely investigated during the past decade. Growth hormone is unique because it regulates the size of the person within the constraints of the genetic program. The somatomedins and insulin growth factors are low molecular weight polypeptides believed to mediate some functions of growth hormone. Epithelial growth factor and nerve growth factor are well-characterized polypeptides that influence the growth and differentiation of epithelial and neural tissues and interact with specific cell surface receptors. The hematopoietins are a family of polypeptide hormones that specifically regulate the proliferation and differentiation of stem cells giving rise to erythrocytes, granulocytes, monocytes, megakaryocytes, and B and T lymphocytes. Platelet-derived growth factor modulates the proliferation of fibroblasts in vitro and may have a role in the development of atherosclerosis and myelofibrosis. New knowledge on the biochemistry and physiology of growth factors will probably have a substantial impact on our understanding of human diseases involving abnormal cell growth.
Article and Author Information
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▸An edited summary of an Interdepartmental Conference arranged by the Department of Medicine of the UCLA School of Medicine; Los Angeles, California.
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▸Authors who wish to cite a section of this conference and specifically indicate its author can use this example for the form of reference:
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HERSCHMAN HR. Nerve growth factor and epidermal growth factor, pp. 000-000. In: GOLDE DW, moderator. Growth factors. Ann Intern Med. 1980;92:650-62.
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▸Requests for reprints should be addressed to David W. Golde, M.D.; Division of Hematology/Oncology, Department of Medicine, UCLA School of Medicine; Los Angeles, CA 90024.
