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Embryonic Determination and Differentiation
- VERNON M. INGRAM, Ph.D.; and
- ROBERT W. KEANE, Ph.D.
Abstract
At the cellular level, development proceeds in a series of stages in which precursor cells are first restricted in their developmental potential (determination) and subsequently express their genetic information as specific tissues (differentiation). This paper discusses the problems encountered in seeking to understand the molecular mechanisms of these processes and describes several model systems. A novel approach involves the inhibition of differentiation by virus transformation of the precursor cells in the chick primary mesenchyme. The transformed cells are cloned, grown to large numbers, and then analyzed biochemically.
Article and Author Information
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▸From the Department of Biology, Massachusetts Institute of Technology; Cambridge, Massachusetts.
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▸Requests for reprints should be addressed to Vernon M. Ingram, Ph.D.; Department of Biology, Massachusetts Institute of Technology; Cambridge, MA 02139.
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- Received December 27, 1979.
- Accepted January 23, 1980.
- © 1980 American College of Physicians
