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Disorders of Phagocyte Chemotaxis
- JOHN I. GALLIN, M.D.;
- DANIEL G. WRIGHT, M.D.;
- HARRY L. MALECH, M.D.;
- JOHN M. DAVIS, M.D.;
- MARK S. KLEMPNER, M.D.; and
- CHARLES H. KIRKPATRICK, M.D.
Abstract
Recent advances in understanding the physiologic and biochemical bases for recruitment of phagocytes to inflammatory sites has led to the recognition of patients who have recurrent infections because of abnormalities of phagocyte chemotaxis. In some of these patients there is abnormal chemoattractant mediator production or regulation, whereas in others there are defects in phagocytic cell function. The cellular defects in chemotaxis can be characterized as either intrinsic defects of the cellular motility apparatus or acquired defects from mediators influencing cell function or from shifts in circulating phagocyte subpopulations. Systematic study of these defects has resulted in functional, biochemical, and ultrastructural characterization of abnormal phagocyte chemotaxis in certain patients, and in some patients study has led to rational approaches for treatment. Clinical trials assessing the efficacy of such pharmacologic agents are underway.
Article and Author Information
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▸An edited transcription of a Combined Clinical Staff Conference at the Clinical Center, Bethesda. Maryland, 14 June 1979, by the National Institute of Allergy and Infectious Diseases and the National Cancer Institute, National Institutes of Health, U.S. Department of Health, Education, and Welfare.
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▸Authors who wish to cite a section of this conference and specifically indicate its author can use this example for the form of the reference:
WRIGHT DG. Relation of chemotaxis to the secretion of neutrophil granule contents, pp. 521-4, In: GALLIN JI, moderator. Disorders of phagocyte chemotaxis. Ann Intern Med. 1980;92:520-38.
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▸Requests for reprints should be addressed to John I. Gallin, M.D.; Building 10, Room 11B18, National Institutes of Health; Bethesda, MD 20205.
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- Received January 15, 1980.
- Accepted January 24, 1980.
