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Combination Antibiotic Therapy of Bacterial Endocarditis
Abstract
A penicillin-aminoglycoside regimen is accepted therapy for enterococcal endocarditis, but use of combinations of antibiotics in other forms of bacterial endocarditis is controversial. This review analyzes in-vitro, experimental animal model, and clinical studies of combination "synergistic" antibiotic treatment for enterococcal, viridans streptococcal, staphylococcal, and gram-negative aerobic bacillary endocarditis. Current recommendations for treatment of these entities are discussed.
Article and Author Information
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▸From the Department of Medicine, University of Virginia School of Medicine; Charlottesville, Virginia.
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▸Requests for reprints should be addressed to Merle A. Sande, M.D.; Department of Medicine, University of Virginia; Charlottesville, VA 22908.
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- Received June 21, 1979.
- Accepted November 20, 1979.
- © 1980 American College of Physicians
