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Histoplasma Meningitis: Diagnostic Value of Cerebrospinal Fluid Serology
Abstract
Two patients with culture-negative chronic meningitis were diagnosed as having Histoplasma capsulatum meningitis based on serial serologic studies; both had antibody in the cerebrospinal fluid as well as the serum. The patients were treated successfully with amphotericin B and had favorable clinical responses. Three control patients with active histoplasmosis and positive serum serologic tests, but without meningeal involvement, did not have antibody in the cerebrospinal fluid. Patients with chronic meningitis of obscure cause should have serial serum and cerebrospinal fluid antibody studies for H. capsulatum.
Article and Author Information
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▸From the Department of Medicine, Ohio State University College of Medicine; Columbus, Ohio.
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▸Requests for reprints should be addressed to Joseph F. Plouffe, M.D.; N-1135, Department of Medicine, Ohio State University; 410 10th Avenue; Columbus, OH 43210.
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- Received June 18, 1979.
- Accepted September 21, 1979.
- © 1980 American College of Physicians
