Effect of Long-Term Propranolol Administration on Parathyroid Hormone and Calcium Concentration in Primary Hyperparathyroidism
- JOSE F. CARO, M.D.;
- JAIME H. CASTRO, M.D.; and
- JOSEPH A. GLENNON, M.D.
- University of Rochester School of Medicine, Rochester, New York
- Thomas Jefferson University, Philadelphia, Pennsylvania
Excerpt
Beta adrenergic agonists have been shown to stimulate parathyroid hormone (PTH) secretion from isolated parathyroid cells. This action can be blocked with the β-adrenergic antagonist propranolol. This response appears to differ from that due to calcium itself, since β-blockade does not alter tissue response to calcium and high calcium concentration does not suppress the response to β-adrenergic stimuli (1-3). Short-term in-vivo studies in animals (4) and humans (5) have also shown PTH responsiveness to β-adrenergic agonists and elimination of this response by propranolol.
We recently found that propranolol significantly decreased serum levels of PTH, alkaline phosphatase, and the incidence of
This 100-word excerpt has been provided in the absence of an abstract.
Article and Author Information
-
Supported in part by Clinical Research Center Grant RR-00044 from Division of Research Resources, National Institutes of Health.
Most Read
