Recurrent Urinary Tract Infections in Men
Characteristics and Response to Therapy
- JAMES W. SMITH, M.D.;
- STEPHEN R. JONES, M.D.;
- WILLIAM P. REED, M.D.;
- ALAN D. TICE, M.D.;
- ROBERT H. DEUPREE, Ph.D.; and
- BERTIL KAIJSER, M.D.
- Dallas, Texas; Portland, Oregon; Albuquerque, New Mexico; Providence, Rhode Island; West Haven, Connecticut; and Goteborg, Sweden
Abstract
All men with recurrent urinary tract infections entered into a study had a positive antibody-coated bacteria test, and 52% had evidence for prostate infection. Escherichia coli infection was present in 74% and urinary tract symptoms in 57% of those randomized. Thirty-eight patients were randomized in a double-blind clinical trial to receive either 10 d of treatment with trimethoprim/sulfamethoxazole or a 12-week course of the drug. The cure rate in patients receiving 12 weeks of therapy (nine of 15) was higher than that in patients receiving a single 10-d course (three of 15); difference was marginally significant (P = 0.06). Recurrences were usually with the same organism, and most (78%) occurred within 4 weeks of discontinuing therapy. This study indicates that a standard 10-d course of therapy usually fails to cure men with recurrent urinary tract infections with a positive antibody-coated bacteria test.
Article and Author Information
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▸From the Veterans Administration Medical Centers, Dallas, Texas, Portland, Oregon, Albuquerque, New Mexico, and Providence, Rhode Island; the Cooperative Studies Program Coordinating Center, West Haven, Connecticut; and the Institute of Medical Microbiology, University of Goteborg, Goteborg, Sweden.
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▸Requests for reprints should be addressed to James W. Smith, M.D.; Infectious Disease Section (111D), Veterans Administration Medical Center, 4500 South Lancaster Road; Dallas, TX 75216.
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- Received May 11, 1979.
- Accepted May 31, 1979.
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