A Familial Occurrence of Allergic Bronchopulmonary Aspergillosis

  1. TERRY S. GRAVES, MD.;
  2. JORDAN N. FINK, M.D.;
  3. ROY PATTERSON, M.D.;
  4. VISWANATH P. KURUP, Ph.D.; and
  5. GERALD T. SCANLON
  1. Milwaukee, Wisconsin

    Abstract

    A family was recently studied in which two brothers with identical HLA serotypes had allergic bronchopulmonary aspergillosis. One of the two had a normal bronchogram. A field investigation of the family residence showed that a barn was the probable source of the organism causing disease in these patients. Immunologic characterization of the family members showed a broad spectrum of response to the environmental exposure.

    Article and Author Information

    • ▸From the Allergy Section, Department of Medicine, and the Department of Radiology, The Medical College of Wisconsin; the Research Service, Woods Veterans Administration Medical Center and Milwaukee County Medical Complex; Milwaukee, Wisconsin; and the Allergy Section, Northwestern University Medical School; Chicago, Illinois.

    • Grant support: Specialized Center of Research (SCOR) Grant HL 15389 from the National Heart, Lung, and Blood Institute; Clinical Research Grant RR 88 from the National Institutes of Health, and the Medical Research Service of the Veterans Administration.

    • ▸Requests for reprints should be addressed to Jordan N. Fink, M.D.; Research Service/151, Veterans Administration Medical Center; Wood, WI 53193.

      • Received December 27, 1978.
      • Accepted May 24, 1979.
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    1. Ann Intern Med September 1, 1979 vol. 91 no. 3 378-382
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