Phenytoin-Induced Toxic Epidermal Necrolysis
- LEONARD E. GATELY III, M.D.; and
- MICHAEL A. LAM, M.D.
Excerpt
Toxic epidermal necrolysis is one of the most severe adverse reactions to a drug. A mortality rate of approximately 25% has been reported (1, 2). The reaction can occur in association with many drugs (3). Fatal cases have been reported with phenytoin (Dilantin) in conjunction with other drugs (4, 5). We report a case of toxic epidermal necrolysis associated with the administration of phenytoin alone.
A 67-year-old man presented to a hospital emergency room with a 2-d history of generalized burning pruritus and burning of his eyes. He was ambulatory, afebrile, and oriented with scaling of the face and erythema
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