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Lymph-Node Bacilliform Bodies Resembling Those of Whipple's Disease in a Patient without Intestinal Involvement
- CHARLES M. MANSBACH II, M.D.;
- JOHN D. SHELBURNE, M.D., Ph.D.;
- ROBERT D. STEVENS, Ph.D.; and
- WILLIAM O. DOBBINS III, M.D.
Abstract
A 38-year-old man developed symptoms of arthralgias and arthritis, lymphadenopathy, and weight loss. An axillary lymph-node biopsy was done in the diagnostic study; a periodic acid Schiff stain, done for evidence of fungal infection, showed periodic acid Schiff reagent-positive macrophages. Electron microscopy showed the typical morphologic features of the bacilliform bodies associated with Whipple's disease to be present in the macrophages of the lymph node. The patient had no intestinal symptoms. The absorption of a variety of substrates was found to be normal. Nine intestinal biopsies showed no organisms similar to those found in his lymph node. On tetracycline therapy, he symptomatically improved. The findings raise the question of the route of infection in Whipple's disease and point up the usefulness of periodic acid Schiff staining of lymph-node biopsies.
Article and Author Information
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▸From the Durham Veterans Administration Hospital; Durham, North Carolina; Division of Gastroenterology, Department of Medicine, and the Department of Pathology, Duke University Medical Center; Durham, North Carolina; and the Division of Gastroenterology, George Washington University Medical Center; Washington, D.C.
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▸Requests for reprints should be addressed to Charles M. Mansbach II, M.D.; Veterans Administration Hospital; 508 Fulton Street; Durham, NC 27705.
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- Received November 21, 1977.
- Accepted March 31, 1978.
- © 1978 American College of Physicians
