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Failure of Chloroquine in Human Babesiosis (Babesia microti)
Case Report and Chemotherapeutic Trials in Hamsters
- LOUIS H. MILLER, M.D., F.A.C.P.;
- FRANKLIN A. NEVA, M.D.; and
- FRED GILL, M.D., F.A.C.P.
Abstract
The failure of a 3-week course of chloroquine to eliminate an infection of Babesia microti acquired on Martha's Vineyard led to tests of selected drugs in hamsters infected with the strain from this patient. The results showed response to several antitrypanosomal drugs (pentamidine and 4,4′-diazoaminobenzamidine) but not to antimalarial drugs (chloroquine, sulfadiazine, and pyrimethamine).
Article and Author Information
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▸From the Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health; Bethesda, Maryland.
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▸Requests for reprints should be addressed to Louis H. Miller, M.D.; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg. 5, Rm. 112; Bethesda, MD 20014.
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- Received June 13, 1977.
- Accepted October 7, 1977.
