Arthralgia and Rubella Immunization

  1. STEPHEN J. LERMAN, M.D.;
  2. MARCIA R. SILVER, M.D.; and
  3. GEORGE A. NANKERVIS, PH.D., M.D.
  1. Pediatric Infectious Disease Unit
    University of Nebraska Medical Center
    Omaha, NE 68105

    Excerpt

    To the editor: In a paper on our 1969 clinical trial of HPV-77:DE-5 live attenuated rubella virus vaccine in adolescent girls and young women (1), we described in detail a 17-year-old vaccinee (subject #281) who developed moderate arthralgia of her knees and hips, moderate-to-severe arthritis of her fingers, and a painful ganglion. We noted that intermittent arthralgia of her knees and hips had persisted for a year after vaccination. We report here an 8-year follow-up.

    Subject #281 is now a 25-year-old resident in internal medicine. At 2-to-3-month intervals and in association with the onset of cool, damp weather, she experiences

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