Pleural Mesothelioma: Clinical Features and Therapeutic Implications
Abstract
A detailed review of the literature was done to define the epidemiology, pathology, clinical features, and treatment of pleural mesothelioma. It appears that pleural mesothelioma accounts for approximately 400 deaths each year in the United States. Asbestos has been definitely implicated in the etiology of this disease. The common clinical features include chest pain, pleural effusion, and radiologic findings of irregular pleural thickening or pleural densities. Therapeutic modalities used in the past have included surgery, radiation therapy, and, more recently, chemotherapy. A combined modality approach to treatment appears more promising.
Article and Author Information
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▸From the Cancer Therapy Evaluation Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, U.S. Department of Health, Education, and Welfare; Bethesda, Maryland.
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▸Requests for reprints should be addressed to Sewa S. Legha, M.D.; Developmental Therapeutics, M. D. Anderson Hospital and Tumor Institute; 6723 Bertner Avenue; Houston, TX 77030.
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- Received December 8, 1976.
- Accepted January 14, 1977.
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