Fatty Liver and Pleural Effusion with Ibuprofen Therapy

Excerpt

New nonsteroidal anti-inflammatory agents have been notably free from serious side effects. We report here a case of fatal fatty metamorphosis of the liver and pleural effusions in an atopic individual with mixed connective tissue disease treated with ibuprofen (Motrin®) and ampicillin.

A 48-year-old woman was first seen on 19 June 1975. She complained of symmetrical polyarthritis for 7 years as well as dry eyes and mouth, Raynaud's phenomenon, dysphagia, and weight loss for the last year. Only aspirin, 2.6 g daily, had been taken for the 3 months before her initial evaluation. She was allergic to streptomycin and para-aminosalicylic