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Guidelines for Drug Therapy in Renal Failure
- WILLIAM M. BENNETT, M.D., F.A.C.P.;
- IRWIN SINGER, M.D., F.A.C.P.;
- THOMAS GOLPER, M.D.;
- PETER FEIG, M.D.; and
- CECIL J. COGGINS, M.D.
Abstract
Five tables are presented that provide guidelines for drug usage in patients with renal insufficiency. The data are derived from the current medical literature. If specific information about a drug is unavailable, emphasis is given to normal pharmacokinetic variables in arriving at recommendations for therapy. Nephrotoxicity or adverse effects in patients with renal disease are noted and adjustments for dialysis suggested.
Article and Author Information
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▸From the Division of Nephrology, Department of Medicine, University of Oregon Health Sciences Center and Veterans Administration Hospital, Portland, Oregon; the Renal-Electrolyte Section, Department of Medicine, University of Pennsylvania School of Medicine and Veterans Administration Hospital, Philadelphia, Pennsylvania; and the Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
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Grant support: by the Portland Veterans Administration Hospital MRIS #0901 (Dr. Bennett); NIH #9-RO1-AMHL-17344 and Veterans Administration Fund #103.14M and 103.6 (Drs. Singer and Feig).
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▸Requests for reprints should be addressed to William M. Bennett, M.D.; Research Services, Veterans Administration Hospital; Portland, OR 97201.
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- Received December 28, 1976.
- Accepted January 18, 1977.
