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Anti-Insulin Receptor Antibodies and Diabetes
- WILLIAM G. BLACKARD, M.D.;
- JAMES H. ANDERSON, M.D.; and
- FRANKLIN MULLINAX, M.D.
- P.O. Box 155, Medical College of Virginia Station
Richmond, VA 23298 -
Physical Science Division USAMRIID
Fort Detrick Frederick, MD 21701 - P.O. Box 263, Medical College of Virginia Station
Richmond, VA 23298
Excerpt
In 1970 we reported the spontaneous remission of severe insulin-resistant diabetes mellitus in a patient with features of scleroderma (1). We now report the apparent cause of this patient's insulin resistance. Serum samples taken during the period of insulin resistance contain immunoglobulin (Ig) G antibodies that block cellular receptors for insulin. Samples taken during remission do not contain these antireceptor antibodies. Our patient is similar to three others reported with severe insulin resistance, antibodies to insulin receptors, and associated features of an immunologic disease (2, 3). However, our patient is unique in that she underwent a spontaneous remission of her
