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Intravascular Hemolysis, Thrombocytopenia, Leukopenia, and Circulating Immune Complexes after Jejunal-Ileal Bypass Surgery
- J. L. MOAKE, M.D.;
- W. V. KAGELER, M.D.;
- P. L. CIMO, M.D.;
- R. W. BLAKELY, M.D.;
- R. D. ROSSEN, M.D.; and
- W. HAESSE, M.D.
Abstract
Two years after jejunal-ileal bypass surgery for obesity, a 25-year-old man developed intravascular hemolysis, thrombocytopenia, and neutropenia. The patient's erythrocytes were coated with complement components (C4/C3) and his serum induced complement-dependent immune lysis of chromium-51-labeled platelets. Serum [125I]-C1q binding activity (a measure of the presence of immune complexes) was increased, and serum C4 and C3 hemolytic titers were depressed. Immune complex-mediated complement activation apparently accounted for the blood cell destruction in this patient.
Article and Author Information
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▸From the Division of Hematology, University of Texas Medical School at Houston; and the Houston Veterans Administration Hospital; Houston, Texas.
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▸Requests for reprints should be addressed to J. L. Moake, M.D.; University of Texas Medical School; 6400 West Cullen Street; Houston, TX 77030.
