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Epstein-Barr Virus and Human Malignancy
- JOHN L. ZIEGLER, M.D.;
- IAN T. MAGRATH, M.B., M.R.C.P.;
- PAUL GERBER, Ph.D.; and
- PAUL H. LEVINE, M.D.
Abstract
The association of the Epstein-Barr virus and two human malignancies, Burkitt's lymphoma and nasopharyngeal carcinoma, is reviewed. Seroepidemiologic, virologic, and immunologic evidence is summarized, and several hypotheses regarding a possible etiologic role for the Epstein-Barr virus in these tumors are presented. With our current state of knowledge we cannot conclude that the Epstein-Barr virus is oncogenic in man, nor can we yet ascertain the biological and clinical significance of its association with Burkitt's lymphoma and nasopharyngeal carcinoma.
Article and Author Information
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▸An edited transcription of a Combined Clinical Staff Conference at the Clinical Center, Bethesda, Maryland, 8 January 1976, by the National Cancer Institute, National Institutes of Health, U.S. Department of Health, Education, and Welfare.
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▸Requests for reprints should be addressed to John L. Ziegler, M.D.; Deputy Clinical Director, National Cancer Institute, Bldg. 10, Rm. 6B-15, National Institutes of Health; Bethesda, MD 20014.
