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Error in Anti-DNA Antibody Radioimmunoassay after Gallium Scanning
- DENNIS TORRETTI, M.D.;
- PATRICK ROONEY, M.D., M.R.C.P.;
- GARY WILLIAMS, M.D., Ph.D.; and
- JOHN L. DECKER, M.D., F.A.C.P.
Abstract
Significant interference with the accurate measurement of anti-DNA antibodies occurs after gallium-67 scanning. The observed effect is dependent on the radioimmunoassay used. False-negative results are observed with a modified Farr assay whereas false-positive results are noted in the millipore filter assay. These spurious values are the result of persistent radioactivity in the patients' sera after administration of 67Ga citrate.
Article and Author Information
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▸From the Arthritis and Rheumatism Branch, National Institute of Arthritis. Metabolism, and Digestive Diseases, National Institutes of Health; Bethesda, Maryland.
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▸Requests for reprints should be addressed to Dennis Torretti, M.D.; Building 10, Room 9N218, National Institutes of Health; Bethesda, MD 20014.
