RSS Feeds
Acetazolamide-Induced Weakness in Paramyotonia Congenita
- JACK E. RIGGS, M.D.;
- ROBERT C. GRIGGS, M.D., F.A.C.P.; and
- RICHARD T. MOXLEY III, M.D.
Abstract
Acetazolamide has been shown to be effective prophylaxis for both hypokalemic and hyperkalemic periodic paralysis. A patient with paramyotonia congenita, a related disorder with myotonia and episodic weakness, was studied during treatment with acetazolamide. Although the patient's myotonia was virtually abolished, severe quadriparesis was produced during each trial of acetazolamide. This response distinguished this patient's condition from other forms of familial periodic paralysis and suggests that acetazolamide may be deleterious to some patients with periodic paralysis.
Article and Author Information
-
▸From the University of Rochester School of Medicine and Dentistry, Department of Neurology, Rochester, New York.
-
▸Requests for reprints should be addressed to Robert C. Griggs, M.D.; Department of Neurology; 601 Elmwood Ave.; Rochester, NY 14642.
-
- Received May 27, 1976.
- Accepted November 10, 1976.
Related Clinical Content
