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Arizona hinshawii Infections
New Cases, Antimicrobial Sensitivities, and Literature Review
- RUDOLPH H. JOHNSON, M.D.;
- LARRY I. LUTWICK, M.D.;
- GERALDINE A. HUNTLEY, B.S.; and
- KENNETH L. VOSTI, M.D.
Abstract
Although disease caused by Arizona hinshawii is known to resemble the spectrum of clinical syndromes seen with Salmonella infections, little is known of their sensitivity to antimicrobials. We present three cases that are illustrative of Arizona sepsis, localized infection, or both; review the literature; and report sensitivities to 12 antimicrobials for 32 human and animal isolates of Arizona hinshawii from various geographic areas. With the exception of erythromycin and streptomycin, most strains were sensitive to many of the commonly used antibiotics. As with Salmonella infections, ampicillin or chloramphenicol appear to be the initial antimicrobial agents of choice for severe infections with A. hinshawii. Definitive antimicrobial therapy must be individualized on the basis of sensitivity testing and with regard to host factors.
Article and Author Information
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▸From the Stanford University Medical Center, Stanford, California; and the Enteric Section, Center for Disease Control, Public Health Service, U.S. Department of Health, Education, and Welfare, Atlanta, Georgia.
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Grant support: Dr. Johnson was supported by an Advanced Research Fellowship from the Bay Area Heart Research Committee, San Francisco, California. Dr. Lutwick was supported by a Research Fellowship from the National Institutes of Health (#5-F22-CA01680-02).
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The use of trade names is for identification only and does not constitute endorsement by the Public Health Service or by the U.S. Department of Health, Education, and Welfare.
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▸Requests for reprints should be addressed to Rudolph H. Johnson, M.D.; Section of Infectious Diseases, Medical Service, Veterans Administration Hospital; 1030 Jefferson Avenue; Memphis, TN 38104.
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- Received March 3, 1976.
- Accepted July 9, 1976.
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